CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2016; 26(01): 135-139
DOI: 10.4103/0971-3026.178364
Neuro

Multiple hypertrophic relapsing remitting cranial neuropathies as an initial presentation of primary CNS lymphoma without any brain or spinal cord lesion

Gaurav V Watane
Department of Radiology and Imaging, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, Maharashtra, India
,
Saumil P Pandya
Department of Radiology and Imaging, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, Maharashtra, India
,
Isha D Atre
Department of Radiology and Imaging, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, Maharashtra, India
,
Foram N Kothari
Department of Radiology and Imaging, Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals, Mumbai, Maharashtra, India
› Author Affiliations

Abstract

Cranial nerve thickening as an initial isolated presentation of CNS lymphoma is rare. Once an extremely rare neoplasm, primary lymphoma of the central nervous system (CNS) now ranks  only next to meningiomas and low-grade astrocytomas in prevalence. Multiple cranial nerve thickening can be a feature of primary CNS lymphoma. Here we report a case of a 45-year-old immunocompetent female who presented with relapsing remitting multiple cranial nerve thickening as an initial feature of primary CNS lymphoma without any other brain or spinal cord lesions.



Publication History

Article published online:
30 July 2021

© 2016. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • References

  • 1 Haldorsen IS, Krossnes BK, Aarseth JH, Scheie D, Johannesen TB, Mella O, et al. Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989-2003: Time trends in a 15-year national survey. Cancer 2007;110:1803-14.
  • 2 van der Sanden GA, Schouten LJ, van Dijck JA, van Andel JP, van der Maazen RW, Coebergh JW; Working Group of Specialists in Neuro-Oncology in the Southern and Eastern Netherlands. Primary central nervous system lymphomas: Incidence and survival in the Southern and Eastern Netherlands. Cancer 2002;94:1548-56.
  • 3 Olson JE, Janney CA, Rao RD, Cerhan JR, Kurtin PJ, Schiff D, et al. The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma: A surveillance, epidemiology, and end results analysis. Cancer 2002;95:1504-10.
  • 4 Coté TR, Manns A, Hardy CR, Yellin FJ, Hartge P. Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome: AIDS/Cancer Study Group. J Natl Cancer Inst 1996;88:675-9.
  • 5 Kasamon YL, Ambinder RF. AIDS-related primary central nervous system lymphoma. Hematol Oncol Clin North Am 2005;19:665-87, vi-vii.
  • 6 Hill QA, Owen RG. CNS prophylaxis in lymphoma: Who to target and what therapy to use. Blood Rev 2006;20:319-32.
  • 7 Haldorsen IS, Espeland A, Larsen JL, Mella O. Diagnostic delay in primary central nervous system lymphoma. Acta Oncol 2005;44:728-34.
  • 8 Morris PG, Abrey LE. Therapeutic challenges in primary CNS lymphoma. Lancet Neurol 2009;8:581-92.
  • 9 Haldorsen IS, Kråkenes J, Krossnes BK, Mella O, Espeland A. CT and MR imaging features of primary central nervous system lymphoma in Norway, 1989-2003. AJNR Am J Neuroradiol 2009;30:744-51.
  • 10 Bühring U, Herrlinger U, Krings T, Thiex R, Weller M, Küker W. MRI features of primary central nervous system lymphomas at presentation. Neurology 2001;57:393-6.
  • 11 Senocak E, Oguz KK, Ozgen B, Mut M, Ayhan S, Berker M, et al. Parenchymal lymphoma of the brain on initial MR imaging: A comparative study between primary and secondary brain lymphoma. Eur J Radiol 2010;79:288-94.
  • 12 Osborn AG. Lymphomas, Hematopoietic and Histiocytic Tumors. In: Renlund A, editor. Osborns Brain Imaging, Pathology and Anatomy. 1 st ed. Manitoba, Canada: Amirsys, Inc; 2013. p. 649.
  • 13 Haldorsen IS, Espeland A, Larsson EM. Central nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol 2011;32:984-92.
  • 14 Matano S, Shirasaki H, Terahata S, Nobata K, Sugimoto T. Thickening of multiple cranial nerves in a patient with extranodal peripheral T-cell lymphoma. J Neuroimaging 2006;16:167-9.
  • 15 Aho TR, Wallace RC, Pitt AM, Sivakumar K. Charcot-Marie-Tooth Disease: Extensive cranial nerve involvement on CT and MR imaging. AJNR Am J Neuroradiol 2004;25:494-7.
  • 16 Slone HW, Blake JJ, Shah R, Guttikonda S, Bourekas EC. CT and MRI findings of intracranial lymphoma. AJR Am J Roentgenol 2005;184:1679-85.
  • 17 Shah R, Roberson GH, Curé JK. Correlation of MR imaging findings and clinical manifestations in neurosarcoidosis. AJNR Am J Neuroradiol 2009;30:953-61.
  • 18 Gaillard F. Leptomeningeal metastases,Radiology Reference Article,Radiopaedia.org [Internet]. Radiopaedia.org. 2014. Available from: http://www.radiopaedia.org/articles/leptomeningeal-metastases. [Last accessed on 2014 Dec 24].
  • 19 Fulbright RK, Erdum E, Sze G, Byrne T. Cranial nerve enhancement in the Guillain-Barré syndrome. AJNR Am J Neuroradiol 1995;16(Suppl):923-5.