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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2016; 26(03): 328-331
DOI: 10.4103/0971-3026.190413
Neuroimaging

Multiparametric 3T MRI evaluation of hereditary spastic paraplegia: A case report

Sonam Priya
Department of Radiology, IPGMER and SSKM Hospital, Kolkata, India
,
Naznin Siddique
Department of Radiology, IPGMER and SSKM Hospital, Kolkata, India
,
Ruchira Das
Department of Radiology, IPGMER and SSKM Hospital, Kolkata, India
,
Archana Singh
Department of Radiology, IPGMER and SSKM Hospital, Kolkata, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Hereditary spastic paraplegia (HSP) is a rare heterogeneous group of familial neurodegenerative disorders characterized by degeneration of the corticospinal tracts and posterior column of the spinal cord. Previously described radiological findings included nonspecific brain abnormalities such as brain atrophy and white matter lesions, as well as atrophy of the corpus callosum and spinal cord. Magnetic resonance spectroscopy may reveal reduced concentrations of normal brain metabolites and elevated levels of myoinositol. Diffusion tensor imaging shows increased mean diffusivity and reduced fractional anisotropy in the periventricular white matter, which is compatible with damaged myelinated axons. We present here two cases of HSP in a single family with typical imaging findings.

Keywords

Corpus callosum atrophy - hereditary - MRI - spastic paraplegia


Publication History

Article published online:
30 July 2021

© 2016. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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