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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2016; 26(03): 337-341
DOI: 10.4103/0971-3026.190424
Neuroimaging

Primary diffuse leptomeningeal oligodendrogliomatosis: A case report and literature review

Amarnath Chellathurai
Department of Radiodiagnosis, Government Stanley Medical College, Chennai, Tamil Nadu, India
,
Jay S Vaidya
Department of Radiodiagnosis, Government Stanley Medical College, Chennai, Tamil Nadu, India
,
Gopinathan Kathirvelu
Department of Radiodiagnosis, Kilpauk Medical College, Chennai, Tamil Nadu, India
,
Periakaruppan Alagappan
Department of Radiodiagnosis, Tamil Nadu Multispeciality Hospital, Omandurar, Chennai, Tamil Nadu, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Primary leptomeningeal oligodendrogliomatosis (PLO) is a rare low-grade intracranial and spinal canal subarachnoid neoplasm without an obvious primary neoplasm in the brain or spinal cord parenchyma. We present here the serial progression of radiological findings of this rare disease in a 2-year-old male child whose clinical status deteriorated over a period of 4 months with the main complaint of partial seizures. During this period, the MR findings progressed from mild hydrocephalus with minimal leptomeningeal enhancement to leptomeningeal multiple cystic lesions in the entire neuraxis including the spine.

Keywords

Leptomeningeal gliomatosis - low-grade glioma - primary leptomeningeal oligodendrogliomatosis


Publication History

Article published online:
30 July 2021

© 2016. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Moore M. Diffuse cerebrospinal gliomatosis, masked by neurosyphilis. J Neuropathol Exp Neurol 1954;13:129-43.
  • 2 Yomo S, Tada T, Hirayama S, Tachibana N, Otani M, Tanaka Y, et al. A case report and review of the literature. J Neurooncol 2007;81:209-16.
  • 3 Riva M, Bacigaluppi S, Galli C, Citterio A, Collice M. Primary leptomeningeal gliomatosis: Case report and review of the literature. Neurol Sci 2005;26:129-34.
  • 4 Debono B, Derrey S, Rabehenoina C, Proust F, Freger P, Laquerrière A. Primary diffuse multinodular leptomeningeal gliomatosis: Case report and review of the literature. Surg Neurol 2006;65:273-82.
  • 5 Somja J, Boly M, Sadzot B, Moonen G, Deprez M. Primary diffuse leptomeningeal gliomatosis: An autopsy case and review of the literature. Acta Neurol Belg 2010;110:325-33.
  • 6 Sceats DJ Jr, Quisling R, Rhoton AL, Ballinger WE, Ryan P. Primary leptomeningeal glioma mimicking an acoustic neuroma: Case report with review of the literature. Neurosurgery 1986;19:649-54.
  • 7 Erlich SS, Davis RL. Spinal subarachnoid metastasis from primary intracranial glioblastoma multiform. Cancer 1978;42:2854-64.
  • 8 Cirak B, Caksen H, Ugras S, Unal O. Primary leptomeningeal astrocytoma in a child. Pediatr Int 2000;42:389-91.
  • 9 Bailey OT, Robitaille Y. Primary diffuse leptomeningeal gliomatosis. Can J Neurol Sci 1985;12:278-81.
  • 10 Abbott KH, Glass B. Intracranial extracerebral (leptomeningeal) glioma: Report of a case and review of the literature, in Proceedings of the Second International Congress on Neuropathology: Part I. Section 8. Neurology and Psychiatry, Amsterdam: Excerpta Medica 1955. p. 786 (Abstract).
  • 11 Sumi SM, Leffman H. Primary intracranial leptomeningeal glioma with persistent hypoglycorrhachia. J Neurol Neurosurg Psychiatry 1968;31:190-4.
  • 12 Horoupian DS, Lax F, Suzuki K. Extracerebral leptomeningeal astrocytoma mimicking a meningioma. Arch Pathol Lab Med 1979;103:676-9.
  • 13 Shuangshoti S, Kasantikul V, Suwanwela N, Suwanwela C. Solitary primary intracranial extracerebral glioma. Case report. J Neurosurg 1984;61:777-81.
  • 14 Kakita A, Wakabayashi K, Takahashi H, Ohama E, Ikuta F, Tokiguchi S. Primary leptomeningeal glioma: Ultrastructural and laminin immunohistochemical studies. Acta Neuropathol 1992;83:538-42.
  • 15 Krief O, Monnier L, Cornu P, Foncin JF, Dormont D, Marsault C. MR of isolated leptomeningeal glioma. AJNR Am J Neuroradiol 1994;15:1782-4.
  • 16 Opeskin K, Anderson RM, Nye DH. Primary meningeal glioma. Pathology 1994;26:72-4.
  • 17 Ng HK, Poon WS. Primary leptomeningeal astrocytoma. Case report. J Neurosurg 1998;88:586-9.
  • 18 Sell M, Mitrovics T, Sander BC. Primary nodular meningeal glioma mimicking metastatic tumor of the cerebellum with diffuse infra- and supratentorialleptomeningeal spread. Clin Neuropathol 2000;19:126-30.
  • 19 Wakabayashi K, Shimura T, Mizutani N, Koide A, Yamagiwa O, Mori F, et al. Primary intracranial solitary leptomeningealglioma: A report of 3 cases. Clin Neuropathol 2002;21:206-13.
  • 20 Michotte A, Chaskis C, Sadones J, Veld PI, Neyns B. Primary leptomeningeal anaplastic oligodendroglioma with a 1p36-19q13 deletion: Report of a unique case successfully treated with temozolomide. J Neurol Sci 2009;287:267-70.
  • 21 Cooper IS, Kernohan JW. Heterotopic glial nests in the subarachnoid space; histopathologic characteristics, mode of origin, and relation to meningeal gliomas. J Neuropathol Exp Neurol 1951;10:16-29.
  • 22 Dietrich PY, Aapro MS, Rieder A, Pizzolato GP. Primary diffuse leptomeningeal gliomatosis (PDLG): A neoplastic cause of chronic meningitis. J Neurooncol 1993;15:275-83.
  • 23 Korein J, Feigin I, Shapiro MF. Oligodendrogliomatosis with intracranial hypertension. Neurology 1957;7:589-94.
  • 24 Bourne TD, Mandell JW, Matsumoto JA, Jane JA Jr, Lopes MB. Primary disseminated leptomeningeal oligodendroglioma with 1p deletion: Case report. J Neurosurg 2006;105(Suppl):465-9.
  • 25 Franceschi E, Cavallo G, Scopece L, Esposti RD, Paioli G, Paioli A, et al. Temozolomide-induced partial response in a patient with primary diffuse leptomeningeal gliomatosis. J Neurooncol 2005;73:261-4.
  • 26 Rogers LR, Estes ML, Rosenbloom SA, Harrold L. Primary leptomeningeal oligodendroglioma: Case report. Neurosurgery 1995;36:166-9.
  • 27 Chen R, Macdonald DR, Ramsay DA. Primary diffuse leptomeningeal oligodendroglioma. Case report. J Neurosurg 1995;83:724-8.
  • 28 Giordana MT, Bradac GB, Pagni CA, Marino S, Attanasio A. Primary diffuse leptomeningeal gliomatosis with anaplastic features. Acta Neurochir (Wien) 1995;132:154-9.
  • 29 Kitahara M, Katakura R, Wada T, Namiki T, Suzuki J. Diffuse form of primary leptomeningeal gliomatosis. Case report. J Neurosurg 1985;63:283-7.
  • 30 Leproux F, Melanson D, Mercier C, Michaud J, Ethier R. Leptomeningeal gliomatosis: MR findings. J Comput Assist Tomogr 1993;17:317-20.
  • 31 Beauchesne P, Pialat J, Duthel R, Barral FG, Clavreul G, Schmitt T, et al. Aggressive treatment with complete remission in primary diffuse leptomeningeal gliomatosis - A case report. J Neurooncol 1998;37:161-7.