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DOI: 10.4103/0971-3026.29000
Structural brain lesions in schizophrenia -magnetic resonance imaging on a mid field magnet
Abstract
Objectives : The brain damage associated with schizophrenia has been established beyond doubt; however, what remains unexplored is the biological nature of transcultural variations. An important reason for this was the lack of mid and high field scanners in developing countries like India. Material and Methods : We undertook a pilot study using a 0.5 Tesla MRI scanner (General Electric Signa Contour) to explore identifiable structural brain lesions in ten randomly selected individuals with schizophrenia. Results: Nine of the ten participants in the series had structural brain changes. The most common findings were ventricular dilatation and prominent cerebral cortical sulci and cerebellar folia. Additionally non-focal white matter lesions were observed in three patients and small right hippocampus was noted in one participant. Conclusions : The study discusses that establishing structural brain lesions with mid field scanners is indeed feasible. The small study sample and heterogeneity of schizophrenia however made it difficult to establish any definite associations
Publication History
Article published online:
02 August 2021
© 2006. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
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References
- 1 Plum F. Prospects for research on schizophrenia.3. Neurophysiology. Neuropathogical findings. Neurosci Res Program Bull 1972; 10: 384-388.
- 2 Diagnostic and statistical Manual for Mental Disorders -IV edition. APA publications.
- 3 Kay SR, Fizsbein A, Opler LA: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizo Bulletin 1987;13:261-267
- 4 Andreason NC. Negative symptoms in schizophrenia. Definition and reliability. Arch Gen Psychiatry 1982;39:784-788.
- 5 Smith RC, Calderon M, Ravichandran GK et al. Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatr Res 1984; 12(2):137-147.
- 6 Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia. A systematic review of volumetric magnetic resonance imaging studies. British journal of Psychiatry 1998,172:110-120.
- 7 Sallet PC, Elkis H, Alves TM, Oliviera JR, Sassi E, de Castro CC, Bussato GF, Gattaz WF. Reduced cortical folding in schizophrenia: An MRI morphometric study. American Journal of Psychiatry 2003,160 (9):1606-1613.
- 8 Paul J Harrison. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999, 122:593-624.
- 9 Coffey CE, Weiner RD, Djang TD, Figiel GS, Soadt SAR, Patterson LJ, Holt PD, Spritzer, CE, Wilkinson WE. Brain anatomic effects of Electroconvulsive therapy. A prospective MRI study. Arch Gen Psychiatry 1991; 48:1013-102.
- 10 Devanand DP, Dwork AJ, Hutchinson ER, Bolwig TG, Sackeim HA: Does ECT alter brain structure? Am J Psychiatry 1994; 151:957-970.