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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2012; 33(03): 182-184
DOI: 10.4103/0971-5851.103151
CASE REPORT

Congenital sacrococcygeal PNET and chemotherapy

Colin Patrick Hawkes
Department of Haematology/ Oncology, Our Lady′s Children′s Hospital, Crumlin, Dublin, Ireland
,
David R Betts
National Centre for Medical Genetics, Crumlin, Dublin, Ireland
,
John O′Brien
Department of Pathology, Our Lady′s Children′s Hospital, Crumlin, Dublin, Ireland
,
Maureen J O′Sullivan
Department of Pathology, Our Lady′s Children′s Hospital, Crumlin, Dublin, Ireland
,
Michael Capra
Department of Haematology/ Oncology, Our Lady′s Children′s Hospital, Crumlin, Dublin, Ireland
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Abstract

We present the case of a congenital localised sacrococcygeal primitive neuroectodermal tumor treated aggressively with surgical resection and modified age-appropriate adjuvant chemotherapy. The conventional combination chemotherapy of vincristine, adriamycin, cyclophosphamide, ifosfamide and etoposide was modified to a regimen including vincristine, adriamicin, cyclophosphamide and actinomycin in order to minimise the predicted toxicity in this age group. Adjuvant "induction" chemotherapy commenced at 4 weeks of age and consisted of four cycles of vincristine, adriamycin and cyclophosphamide at 50%, 75%, 75% and 100% of recommended doses (vincristine 0.05 mg/kg, adriamycin 0.83 mg/kg daily × 2, cyclophosphamide 40 mg/kg) at 3-weekly intervals. This was followed by four cycles of "maintenance" chemotherapy with vincristine (0.025 mg/kg), actinomycin (0.025 mg/kg) and cyclophosphamide (36 mg/kg) at full recommended doses. Cardioxane at a dose of 16.6 mg/kg was infused immediately prior to the adriamycin. Our patient is thriving at 19 months out from end of treatment.

Keywords

Chemotherapy - neonatal - peripheral primitive neuroectodermal tumor - primitive neuroectodermal tumor


Publication History

Article published online:
02 August 2021

© 2012. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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