Abstract
Prostate gland is a fibromusculoglandular structure situated at the neck of urinary
bladder. So, enlargement or growth of prostate due to nodular hyperplasia (NHP) or
prostatic intraepithelial neoplasia (PIN) or adenocarcinoma may give rise to bladder
outlet obstruction. Malignant growth i.e., PIN or adenocarcinoma cases are associated
with increased blood level of prostate-specific antigen (PSA) and increased expression
of different sex-steroid receptors because the growth is dependent on the interactions
of androgen, progesterone and estrogen. The aim of our study is to correlate the histopathology,
PSA levels and expression of different sex-steroid receptors by immunohistochemistry
in different prostatic growth lesions. Among the total 50 cases received, inclusive
of transurethral resection of prostate (TURP), transrectal ultrasound-guided biopsy
and radical prostatectomy, 34 cases were diagnosed as NHP, 4 cases as PIN and 12 cases
as adenocarcinoma histopathologically. Serum PSA values above 10 ng/ml were seen in
2 cases of PIN and 11 cases of adenocarcinoma and none of NHP. Estrogen receptor (ER)
() expressions were negative in all cases. Progesterone receptor (PR) expressions
were strongly positive in 35% cases of both NHP and adenocarcinoma, whereas androgen
receptor (AR) expressions were strong among all cases of adenocarcinoma and only in
four cases of NHP. By observing these findings it can be suggested that antiandrogen
and antiprogesterone therapy simultaneously will do better than antiandrogen alone
in treating prostatic growth lesions.
Keywords
Androgen receptor - immunohistochemistry - progesterone receptor - prostatic growth
- prostate-specific antigen
