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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(01): 79-82
DOI: 10.4103/0971-5851.133727
CASE REPORT

Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

M Appachu Appachu
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
,
Samit Purohit
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
,
K.C. Lakshmaiah
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
,
B.S. Kumari Aruna
Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
,
L Appaji
Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
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Abstract

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.

Keywords

Encephalopathy syndrome - PRES - steroid induced encephalopathy


Publication History

Article published online:
19 July 2021

© 2014. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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