Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

M Appachu Appachu; Samit Purohit; K.C. Lakshmaiah; B.S. Kumari Aruna; L Appaji

doi:10.4103/0971-5851.133727

Indian Journal of Medical and Paediatric Oncology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(01): 79-82
DOI: 10.4103/0971-5851.133727

CASE REPORT

Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

Authors

M Appachu Appachu

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
Samit Purohit

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
K.C. Lakshmaiah

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
B.S. Kumari Aruna

Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India
L Appaji

Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India

Abstract

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Abstract

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.

Keywords

Encephalopathy syndrome - PRES - steroid induced encephalopathy

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Referenzen

References
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