The seroprevalence of Kaposi′s sarcoma associated herpes virus and human herpes virus-6 in pediatric patients with cancer and healthy children in a Turkish pediatric oncology center

Nurdan Tacyildiz; Handan Ugur Dincaslan; Halil Ozdemir; Gulsan Yavuz; Emel Unal; Aydan Ikinciogullari; Figen Dogu; Deniz Guloglu; Emine Suskan; Kenan Kose

doi:10.4103/0971-5851.142039

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(03): 221-225
DOI: 10.4103/0971-5851.142039

ORIGINAL ARTICLE

The seroprevalence of Kaposi′s sarcoma associated herpes virus and human herpes virus-6 in pediatric patients with cancer and healthy children in a Turkish pediatric oncology center

Authors

Nurdan Tacyildiz

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey
Handan Ugur Dincaslan

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey
Halil Ozdemir

Department of Pediatric Infection Diseases, Ankara University Medical School, Ankara, Turkey
Gulsan Yavuz

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey
Emel Unal

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey
Aydan Ikinciogullari

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey
Figen Dogu

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey
Deniz Guloglu

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey
Emine Suskan

Department of Pediatrics, Ankara University Medical School, Ankara, Turkey
Kenan Kose

Department of Biostatistics, Ankara University Medical School, Ankara, Turkey

Abstract

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Abstract

Background: Many studies have tried to be establish a pathogenic role for human herpesvirus-6 and -8 (HHV-6, HHV-8) in malignant diseases, but whether these viruses plays a role in these pathologies remains unclear. HHV-6 and HHV-8 seropositivity were shown in a healthy population. There is no published data in Turkey about seroprevalence of these viruses. We aimed to determine the seroprevalence of HHV-6 and HHV-8 in pediatric cancer patients and to compare with healthy Turkish children′s viral seroprevalence. Patients and Methods: Ninety-three pediatric cancer patients and 43 age-matched healthy children were included in the study. All sera were screened for antibodies to HHV-6 and HHV-8 by ELISA. Results: HHV-8 immunoglobulin G (IgG) was positive in 3.3% of lymphoma patients, in 4.8% of acute lymphoblastic leukemia (ALL) patients, in 4.8% of retinoblastoma patients and in 7% of healthy children. There was no significant difference in HHV-8 seroprevelance between these groups. HHV-6 seroprevalence was 81% in ALL patients, 70% in lymphoma group, 81% in retinoblastoma patients and 69.8% in healthy children. Although there was no significant difference in HHV-6 prevalence between healthy children and pediatric cancer patients, HHV-6 seropositivity tended to be higher in retinoblastoma patients under age of 4 years (odds ratio: 2.925). Conclusion: HHV-6 seroprevalence was higher than HHV-8 seropositivity in our study. Viral studies related HHV-6 seroprevelance in retinoblastoma patients would be useful to clarify if there is any etiological association between HHV-6 and retinoblastoma.

Keywords

Herpesvirus-6 - herpesvirus-8 - pediatric malignancies

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References

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