The seroprevalence of Kaposi′s sarcoma associated herpes virus and human herpes virus-6 in pediatric patients with cancer and healthy children in a Turkish pediatric oncology center

Nurdan Tacyildiz; Handan Ugur Dincaslan; Halil Ozdemir; Gulsan Yavuz; Emel Unal; Aydan Ikinciogullari; Figen Dogu; Deniz Guloglu; Emine Suskan; Kenan Kose

doi:10.4103/0971-5851.142039

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(03): 221-225
DOI: 10.4103/0971-5851.142039

ORIGINAL ARTICLE

The seroprevalence of Kaposi′s sarcoma associated herpes virus and human herpes virus-6 in pediatric patients with cancer and healthy children in a Turkish pediatric oncology center

Nurdan Tacyildiz

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey

,

Handan Ugur Dincaslan

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey

,

Halil Ozdemir

Department of Pediatric Infection Diseases, Ankara University Medical School, Ankara, Turkey

,

Gulsan Yavuz

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey

,

Emel Unal

Department of Pediatrics Oncology, Ankara University Medical School, Ankara, Turkey

,

Aydan Ikinciogullari

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey

,

Figen Dogu

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey

,

Deniz Guloglu

Department of Pediatric Immunology, Ankara University Medical School, Ankara, Turkey

,

Emine Suskan

Department of Pediatrics, Ankara University Medical School, Ankara, Turkey

,

Kenan Kose

Department of Biostatistics, Ankara University Medical School, Ankara, Turkey

› Author Affiliations

Abstract

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Abstract

Background: Many studies have tried to be establish a pathogenic role for human herpesvirus-6 and -8 (HHV-6, HHV-8) in malignant diseases, but whether these viruses plays a role in these pathologies remains unclear. HHV-6 and HHV-8 seropositivity were shown in a healthy population. There is no published data in Turkey about seroprevalence of these viruses. We aimed to determine the seroprevalence of HHV-6 and HHV-8 in pediatric cancer patients and to compare with healthy Turkish children′s viral seroprevalence. Patients and Methods: Ninety-three pediatric cancer patients and 43 age-matched healthy children were included in the study. All sera were screened for antibodies to HHV-6 and HHV-8 by ELISA. Results: HHV-8 immunoglobulin G (IgG) was positive in 3.3% of lymphoma patients, in 4.8% of acute lymphoblastic leukemia (ALL) patients, in 4.8% of retinoblastoma patients and in 7% of healthy children. There was no significant difference in HHV-8 seroprevelance between these groups. HHV-6 seroprevalence was 81% in ALL patients, 70% in lymphoma group, 81% in retinoblastoma patients and 69.8% in healthy children. Although there was no significant difference in HHV-6 prevalence between healthy children and pediatric cancer patients, HHV-6 seropositivity tended to be higher in retinoblastoma patients under age of 4 years (odds ratio: 2.925). Conclusion: HHV-6 seroprevalence was higher than HHV-8 seropositivity in our study. Viral studies related HHV-6 seroprevelance in retinoblastoma patients would be useful to clarify if there is any etiological association between HHV-6 and retinoblastoma.

Keywords

Herpesvirus-6 - herpesvirus-8 - pediatric malignancies

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References

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