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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2015; 36(04): 255-260
DOI: 10.4103/0971-5851.171550
ORIGINAL ARTICLE

Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution

Rahul Narayan Maddi
Department of Medical Oncology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, India
,
Vijay Gandhi Linga
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Kalpathi Krishnamani Iyer
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Joseph Stalin Chowdary
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Sadashivudu Gundeti
Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
,
Raghunadharao Digumarti
Director and Department of Medical Oncology, Tata Memorial Center, Vishakapatnam, Andhra Pradesh, India
,
Tara Roshini Paul
Department of Pathology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India
› Institutsangaben Financial support and sponsorship Nil.
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Abstract

Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse. Aims: Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities. Settings and Design: This is a retrospective analysis from the case records from a single institution. Materials and Methods: Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age ≥18 years) underwent treatment at our institution. Statistical Analysis: Kaplan-Meyer curves were used to calculate the PFS and OS. Results: The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%). Conclusions: Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively.

Keywords

Chemotherapy and toxicities - Hodgkin lymphoma - survival


Publikationsverlauf

Artikel online veröffentlicht:
12. Juli 2021

© 2015. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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