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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2016; 37(04): 260-264
DOI: 10.4103/0971-5851.195738
ORIGINAL ARTICLE

Managing metastatic renal cell carcinoma-challenges, pitfalls, and outcomes in the real world

Karnam Ashok Kumar
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
,
Gundeti Sadashivudu
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
,
K V Krishnamani
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
,
Vijay Gandhi Linga
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
,
Lakshmi Srinivas Maddali
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
,
Raghunadha Rao Digumarti
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Introduction: Renal cell carcinoma (RCC) is the most common cancer of the kidney accounting for 85% of renal tumors. Metastatic RCC (mRCC) had a poor prognosis and with the introduction of tyrosine-kinase inhibitors, such as sunitinib, pazopanib the outcomes improved. There is only one study reported from India on the use of sunitinib in mRCC. We present our analysis of mRCC and use of sunitinib at our institute over 5 years. Materials and Methods: All patients with mRCC receiving sunitinib were analyzed with respect to patient characteristics, response, toxicity, and outcomes. Results: A total of 108 patients were seen during the study period. The male to female ratio was 9.8:1. The median age of patients at presentation was 58 years (range: 15–80 years). Of the 108 patients, 68.51% had metastatic disease at initial presentation. The most common sites of metastases were lung followed by bone. Of the 97 patients eligible for sunitinib, only 76 received at least one cycle of sunitinib, out of which only 48 received further cycles (range: 2–36). The median progression-free survival (PFS) and overall survival (OS) in our patients were 10.2 and 28.2 months, respectively. The most common adverse effect noticed in our population was mucositis followed by hand-foot syndrome. Conclusion: Sunitinib is an option for the treatment of mRCC and shows a good PFS in Indian patients. Median OS and PFS in this study are similar to other reported studies despite the presence of poor risk factors in the patient population. The pitfall in this study is significant attrition due to poor compliance to treatment and follow-up, which is a major factor in the clinic thereby compromising outcomes.

Keywords

Metastatic renal cell carcinoma - outcomes - sunitinib


Publication History

Article published online:
12 July 2021

© 2016. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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