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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2010; 31(03): 91-93
DOI: 10.4103/0971-5851.73600
CASE REPORT

Disease recurrence in a transplant kidney in a patient with extramedullary plasmacytoma

Pooja Binnani
Department of Nephrology, Jaslok Hospital and Research Centre, Mumbai, India
,
M M Bahadur
Department of Nephrology, Jaslok Hospital and Research Centre, Mumbai, India
,
Nikhil Kedia
Department of Nephrology, Jaslok Hospital and Research Centre, Mumbai, India
,
Prakash Sharbidre
Department of Nephrology, Jaslok Hospital and Research Centre, Mumbai, India
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Abstract

Renal transplantation in patients with malignancy is controversial. Renal transplantation is generally not considered for patients with multiple myeloma (MM) because of their extremely poor prognosis. There are few reports of MM recurrence among kidney transplant recipients. We present a case of disease relapse of plasmacytoma in a transplanted kidney. We present a patient with extramedullary plasmacytoma, who responded well to chemotherapy and underwent allogenic renal transplantation. He relapsed after 4 years with progression to extramedullary plasmacytoma. Despite minimal clinical symptoms, the patient had developed myeloma cast nephropathy and acute renal failure. His renal failure settled after excision of tumor. Extramedullary plasmacytoma as a mode of relapse is highly unusual. Experience of renal transplantation in MM is limited. In the literature, the recurrence of MM is mentioned as a severe complication with a poor graft prognosis. Extramedullary plasmacytoma as a mode of relapse is highly unusual. It should not be considered as a contraindication for transplantation. Renal transplantation for patients with end stage renal disease (ESRD) due to MM is possible. But large prospective studies are needed to develop a strategy for preventing multiple myeloma recurrence.

Keywords

Cast nephropathy - disease recurrence - plasmacytoma


Publication History

Article published online:
19 November 2021

© 2010. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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