Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(04): 233-237
DOI: 10.4103/0971-5851.95149
CASE REPORT

Rare metastatic prostatic malignancy: A case report and approach to management

M Vamshi Krishna
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
,
Kumar Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
,
Vanita Noronha
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
,
Santosh Menon
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
,
Sumeet Dua
Department of Nuclear Medicine, Tata Memorial Hospital, Parel, Mumbai, India
,
V Rangarajan
Department of Nuclear Medicine, Tata Memorial Hospital, Parel, Mumbai, India
,
H B Tangaonkar
Department of Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
› Author Affiliations
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

We present a patient with metastatic leiomyosarcoma of the prostate who achieved complete response with chemotherapy. A 70 years old male patient presented with urinary tract symptoms and a prostatic mass. After having been treated as carcinoma prostate, he presented with progressive pelvic mass, lung and bone metastases to our hospital. Repeat biopsy was suggestive of prostatic leiomyosarcoma. He was treated with chemotherapy with the ifosfamide-epirubicin regimen and achieved complete remission on positron emission tomography/computerized tomography after three cycles. He was given a total of six cycles of chemotherapy and continues to be disease-free after 8 months. Although adenocarcinomas are the commonest prostatic malignancies in the elderly, a careful evaluation is essential to rule out alternative diagnoses. Our case report illustrates the potential role of combination chemotherapy in the management of advanced leiomyosarcoma of the prostate. The literature on this entity is reviewed.

Keywords

Chemotherapy - leiomyosarcoma - positron emission tomography/computerized tomography - prostate


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Zelefisky MJ, Eastham JA, Sartor AO. Cancer of the prostate. In: Devita VT, Lawrenace PS, Rosenberg SA, Editors. Cancer: Principles and practices of oncology. 9 th Ed. Philndelphia; Lippincott, Willam, Wilkins. P. 1220-71.
  • 2 Hansel DE, Herawi M, Montgomery E, Epstein JI. Spindle cell lesions of the adult prostate. Mod Pathol 2007;20:148-58.
  • 3 Gaudin PB, Rosai J, Epstein JI. Sarcomas and related proliferative lesions of specialized prostatic stroma: A clinicopathologic study of 22 cases. Am J Surg Pathol 1998;22:148-62.
  • 4 Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: Where are we now? J Clin Pathol 2008;61:428-37.
  • 5 Iwata J, Fletcher CD. Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: A systematic study of 100 cases. Pathol Int 2000;50:7-14.
  • 6 Rioja J, Rodríguez-Fraile M, Lima-Favaretto R, Rincón-Mayans A, Peñuelas-Sánchez I, Zudaire-Bergera JJ, et al. Role of positron emission tomography in urological oncology. BJU Int 2010;106:1578-94.
  • 7 Cheville JC, Dundore PA, Nascimento AG, Meneses M, Kleer E, Farrow GM, et al. Leiomyosarcoma of the prostate. Report of 23 cases." Cancer 1995;76:1422-7.
  • 8 Vandoros GP, Manolidis T, Karamouzis MV, Gkermpesi M, Lambropoulou M, Papatsoris AG, et al. Leiomyosarcoma of the Prostate: Case report and Review of 54 Previously Published Cases, Sarcoma 2008; article ID: 458709.
  • 9 Sexton WJ, Lance RE, Reyes AO, Pisters PW, Tu SM, Pisters LL. Adult prostate sarcoma: The M. D. Anderson cancer center experience. J Urol 2001;166:521-5.
  • 10 Dotan ZA, Tal R, Golijanin D, Snyder ME, Antonescu C, Brennan MF, et al. Adult genitourinary sarcoma: The 25-year Memorial Sloan-Kettering experience. J Urol 2006;176:2033-9.
  • 11 Chen HJ, Xu M, Zhang L, Zhang YK, Wang GM. Prostate sarcoma: A report of 14 cases. Zhonghua Nan Ke Xue 2005;11:683-5.
  • 12 Ahlering TE, Weintraub P, Skinner DG. Management of adult sarcomas of the bladder and prostate. J Urol 1988;140:1397-9.