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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2012; 33(01): 36-41
DOI: 10.4103/0971-5851.96967
ORIGINAL ARTICLE

Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer

Syed Ahmed Taqi
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India
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Abstract

Aims: Special attention has been given to define the biochemical changes in cell-surface glycoproteins and glycolipids that take place during malignant transformation. This study was thus designed to explore the clinical utility of total and lipid bound sialic acid (LSA) in patients with oral precancer and oral cancer. Materials and Methods: Blood samples were obtained from 95 subjects divided into three groups, namely healthy individuals, oral cancer, and precancer. Serum total and LSA levels were determined using periodate-thiobarbituric acid method and Katopodis et al. method, respectively. Finally, spectrophotometricreadings were obtained. Results: Mean values of serum sialic acid (total and lipid bound) in oral cancer were significantly higher than control and the precancer group (P<0.001). The multivariate analysis data revealed progressive rise in total and LSA, which was statistically significant with clinical stage of the cancer. Conclusion: Serum sialic acid levels can differentiate between patients with oral precancer and oral cancer. It could be used as an adjunct to diagnosis, monitor response to therapy, and assess the staging of cancer.

Keywords

Katopodis - oral cancer - oral precancer - periodate-thiobarbituric acid - sialic acid - spectrophotometer


Publication History

Article published online:
13 April 2022

© 2012. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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