PDF herunterladen
CC BY-NC-ND 4.0 · J Lab Physicians 2015; 7(02): 124-127
DOI: 10.4103/0974-2727.163133
Case Report

Achromobacter Xylosoxidans Bloodstream Infection in Elderly Patient with Hepatocellular Carcinoma: Case Report and Review of Literature

Kausalya Raghuraman
Department of Laboratory Medicine, Delhi State Cancer Institute, New Delhi, India
,
Nishat H Ahmed
Department of Laboratory Medicine, Delhi State Cancer Institute, New Delhi, India
,
Frincy K Baruah
Department of Laboratory Medicine, Delhi State Cancer Institute, New Delhi, India
,
Rajesh K Grover
Department of Clinical Oncology, Delhi State Cancer Institute, New Delhi, India
› Institutsangaben Financial support and sponsorship Nil.
› Weitere Informationen
Auch verfügbar auf
  als PDF herunterladen Lizenzen und Reprints

ABSTRACT

Achromobacter xylosoxidans is a nonfermentative Gram-negative organism, known to cause opportunistic infection in humans. We report a case of septicemia in a 76-year-old male patient with underlying hepatocellular carcinoma due to A. xylosoxidans, which showed a different antimicrobial susceptibility pattern from what is usually reported. From aerobic blood culture of the patient, A. xylosoxidans was isolated which was found to be sensitive to amoxicillin-clavulanic acid, piperacillin-tazobactam, ceftazidime, cefoperazone-sulbactam, meropenem, minocycline, tigecycline, and trimethoprim/sulfamethoxazole. The patient recovered with amoxicillin-clavulanic acid treatment, which was given empirically to the patient. The present case highlights the possible role of amoxicillin-clavulanic acid for treatment of bloodstream infection with A. xylosoxidans.

Keywords

Achromobacter xylosoxidans - amoxicillin-clavulanic acid - blood stream infection


Publikationsverlauf

Artikel online veröffentlicht:
19. April 2020

© 2015.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • REFERENCES

  • 1 Turel O, Kavuncuoglu S, Hosaf E, Ozbek S, Aldemir E, Uygur T, et al.Bacteremia due to Achromobacter xylosoxidansin neonates: Clinical features and outcome. Braz J Infect Dis 2013;17:450-4.
  • 2 Peterson RR, Anandan S, Ebenezer K, Agarwal I. Achromobacter xylosoxidans septicemia in a neonate. Paediatr Infect Dis 2014;6:99-101.
  • 3 Weitkamp JH, Tang YW, Haas DW, Midha NK, Crowe JE Jr. Recurrent Achromobacter xylosoxidans bacteremia associated with persistent lymph node infection in a patient with hyper-immunoglobulin M syndrome. Clin Infect Dis 2000;31:1183-7.
  • 4 Aisenberg G, Rolston KV, Safdar A. Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003). Cancer 2004;101:2134-40.
  • 5 Padmaja K, Lakshmi V, Rao MA, Mishra RC, Rosy C, Sritharan V. Prosthetic valve endocarditis with aortic root abscess due to Achromobacter xylosoxidans subsp denitrificans ߝ A rare case report. Int J Infect Control (Serial Online) 2013;9:1-5. Available from: http://www.ijic.info. [Last accessed on 2014 Dec 14].
  • 6 Clinical and Laboratory standards Institute, Performance standards for Antimicrobial Susceptibility testing; Twenty fourth informational supplement CLSI document M 100-S 24. Vol. 34. Wayne, PA: Clinical and Laboratory Standards Institute; 2014. p. 1.
  • 7 Al-Jasser AM, Al-Anazi KA. Complicated septic shock caused by Achromobacter xylosoxidans bacteremia in a patient with acute lymphoblastic leukaemia. Libyan J Med 2007;2:218-9.
  • 8 Gómez-Cerezo J, Suárez I, Ríos JJ, Peña P, García de Miguel MJ, de José M, et al. Achromobacter xylosoxidans bacteremia: A 10-year analysis of 54 cases. Eur J Clin Microbiol Infect Dis 2003;22:360-3.
  • 9 Legrand C, Anaissie E. Bacteremia due to Achromobacter xylosoxidans in patients with cancer. Clin Infect Dis 1992;14:479-84.
  • 10 Duggan JM, Goldstein SJ, Chenoweth CE, Kauffman CA, Bradley SF. Achromobacter xylosoxidans bacteremia: Report of four cases and review of the literature. Clin Infect Dis 1996;23:569-76.
  • 11 Shie SS, Huang CT, Leu HS. Characteristics of Achromobacter xylosoxidans bacteremia in northern Taiwan. J Microbiol Immunol Infect 2005;38:277-82.
  • 12 Kaur M, Ray P, Bhatty M, Sharma M. Epidemiological typing of clinical isolates of Achromobacter xylosoxidans: Comparison of phenotypic and genotypic methods. Eur J Clin Microbiol Infect Dis 2009;28:1023-32.
  • 13 Krause ML, Sohail MR, Patel R, Wittich CM. Achromobacter piechaudii bloodstream infection in an immunocompetent host. Am J Case Rep 2012;13:265-7.
  • 14 Otta S, Swain B, Panigrahy R, Panda K, Debata NK. Achromobacter xylosoxidans: A rare pathogen for community acquired acute pancreatitis. JMM case reports (serial online) 2014;1:1-3. Available from http://jmmcr.sgmjournals.org. [Last accessed on Dec 15 2014].
  • 15 Ng ZY, Fang G, Leo KW. Resolution of concomitant Achromobacter xylosoxidans burn wound infection without adjustment of antimicrobial therapy. Indian J Plast Surg 2014;47:137-40.