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CC BY-NC-ND 4.0 · J Lab Physicians 2012; 4(01): 005-009
DOI: 10.4103/0974-2727.98662
Original Article

Mean Platelet Volume in Type 2 Diabetes Mellitus

Thomas Alex Kodiatte
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Udaya Kumar Manikyam
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Suraksha Bellur Rao
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Thej Mothakapalli Jagadish
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Madhavi Reddy
Department of Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Harendra Kumar Malligere Lingaiah
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
,
Venkataswamy Lakshmaiah
Department of Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
› Author Affiliations Source of Support: Nil
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ABSTRACT

Context: diabetes mellitus is a global pandemic. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Larger platelets are younger and exhibit more activity.

Aims: to determine the MPV in diabetics compared to nondiabetics, to see if there is a difference in MPV between diabetics with and without vascular complications, and to determine the correlation of MPV with fasting blood glucose, glycosylated hemoglobin (HbA1c), body-mass index, and duration of diabetes in the diabetic patients.

Materials and Methods: platelet counts and MPV were measured in 300 Type 2 diabetic patients and 300 nondiabetic subjects using an automated blood cell counter. The blood glucose levels and HbA1c levels were also measured. Statistical evaluation was performed by SPSS using Student’s t test and Pearson correlation tests.

Results: the mean platelet counts and MPV were higher in diabetics compared to the nondiabetic subjects [277.46 ± 81 X 109/l vs. 269.79 ± 78 X 109/l (P= 0.256)], 8.29 ± 0.74 fl versus 7.47 ± 0.73 fl (P= 0.001), respectively. MPV showed a strong positive correlation with fasting blood glucose, postprandial glucose and HbA1C levels (P=0.001).

Conclusions: our results showed significantly higher MPV in diabetic patients than in the nondiabetic subjects. This indicates that elevated MPV could be either the cause for or due to the effect of the vascular complications. Hence, platelets may play a role and MPV can be used as a simple parameter to assess the vascular events in diabetes.

Keywords

Diabetes mellitus - hyperglycemia - mean platelet volume


Publication History

Article published online:
09 May 2020

© 2012.

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  • REFERENCES

  • 1 Mahsud MAJ, Khan A, Hussain J. Hematological Changes in Tobacco using Type 2 Diabetic Patients. Gomal J Med Sci 2010;8:8-11.
  • 2 King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-31.
  • 3 World Health Organization August 2011. Available from: http://www.who.int/mediacentre/factsheets/fs312/en/ [Last accessed on 2011 Nov 17].
  • 4 Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009;23:89-94.
  • 5 Hekimsoy Z, Payzinb B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18:173-6.
  • 6 Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J 2008;49:114-6.
  • 7 Bae SH, Lee J, Roh KH, Kim J. Platelet activation in patients with diabetic retinopathy. Korean J Ophthalmol 2003;17:140-4.
  • 8 Maitra A. The Endocrine System. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran Pathologic Basis of Disease. 8th ed. New Delhi: Elsevier; 2010. p. 1097-164.
  • 9 Mitchell RN. Hemodynamic Disorders, Thromboembolic Disease and Shock. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran Pathologic Basis of Disease. 8th ed. New Delhi: Elsevier; 2010. p. 111-34.
  • 10 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Sabaté M, Jimenez-Quevedo P, et al. Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005;54:2430-5.
  • 11 Colwell JA, Nesto RW. The platelet in diabetes-focus on prevention of ischemic events. Diabetes Care 2003;26:2181-8.
  • 12 Ateş O, Kiki I, Bilen H, Keleş M, Koçer I, Kulaçoğlu DN et al . Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus. Eur J Gen Med 2009;6:99-102.
  • 13 Chang HA, Hwang HS, Park HK, Chun MY, Sung JY. The Role of Mean Platelet Volume as a Predicting Factor of Asymptomatic Coronary Artery Disease. Korean J Fam Med 2010;31:600-6.
  • 14 Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011;16:86-9.
  • 15 Bern MM. Platelet functions in diabetes mellitus. Diabetes 1978;27:342-50.
  • 16 Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL. Platelet dysfunction in type 2 diabetes. Diabetes Care 2001;24:1476-85.
  • 17 Schneider DJ. Factors contributing to increased platelet reactivity in people with diabetes. Diabetes Care 2009;32:525-7.
  • 18 Kakouros N, Rade JJ, Kourliouros A, Resar JR. Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective. Int J Endocrinol 2011;2011:742719.
  • 19 Yngen M, Norhammar A, Hjemdahl P, Wallén NH. Effects of improved metabolic control on platelet reactivity in patients with type 2 diabetes mellitus following coronary angioplasty. Diab Vasc Dis Res 2006;3:52-6.
  • 20 Sewell R, Ibbotson RM, Phillips R, Carson P. High mean platelet volume after myocardial infarction: is it due to consumption of small platelets? Br Med J (Clin Res Ed) 1984;289:1576-8.
  • 21 Boos CJ, Lip GY. Assessment of mean platelet volume in coronary artery disease- what does it mean? Thromb Res 2007;120:11-3.
  • 22 Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004;15:475-8.