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CC BY-NC-ND 4.0 · World J Nucl Med 2015; 14(03): 216-218
DOI: 10.4103/1450-1147.161730
Case report

Radiosynovectomy of Proximal Interphalangeal Joint Synovitis in Rheumatoid Arthritis Treated with Rhenium-188 Labeled Tin-colloid and Imaging with Single-photon Emission Computerized Tomography/Computed Tomography: A First Case Report

Koramadai Kamaleshwaran
Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
,
Venkataraman Rajamani
1   Department of Rheumatology, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
,
Boopathi Krishnan
2   Department of Orthopedics, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
,
Madhav Mallia
3   Radiopharmaceuticals Chemistry Section, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
,
Radhakrishnan Kalarikal
Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
,
Vyshakh Mohanan
Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
,
Ajit Shinto
Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
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Rheumatoid arthritis (RA) is a chronic disease that is mainly characterized by the asymmetric erosive synovitis, particularly affecting peripheral joints. Radiation synovectomy or radiosynovectomy (RSV), also known as radiosynoviorthesis was first described in 1950′s as an adjuvant treatment for RA. RSV is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. As a generator-produced β-emitting radionuclide, the importance of rhenium-188 (Re-188) for radionuclide therapy is increasing rapidly. There are previous reports which used Re-188 tin colloid in knee joint synovitis, but use of Re-188 tin colloid in small joint is not yet reported. We describe the use of Re-188 tin colloid in a 45-year-old female who presented with right 4 th proximal interphalangeal joint synovitis due to rheumatoid arthritis.

Keywords

Radiosynovectomy - rhenium-188 tin colloid - small joint - single-photon emission computerized tomography/computed tomography


Publication History

Article published online:
21 May 2022

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