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CC BY-NC-ND 4.0 · World J Nucl Med 2016; 15(01): 24-29
DOI: 10.4103/1450-1147.167585
Original article

Outcome of Radioiodine Therapy in a West African Population

Yetunde Onimode
1   Department of Nuclear Medicine, University College Hospital, Ibadan, Oyo State, Nigeria
2   Department of Radiotherapy, University of Ibadan, Ibadan, Oyo State, Nigeria
,
Alfred Ankrah
3   Department of Nuclear Medicine, National Centre for Radiotherapy and Nuclear Medicine, Korle Bu Hospital, Accra, Ghana
,
Kayode Adedapo
1   Department of Nuclear Medicine, University College Hospital, Ibadan, Oyo State, Nigeria
4   Department of Nuclear Medicine, University College Hospital, Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
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Hyperthyroidism continues to be a pressing public health concern in West Africa. Its prevalence in Africa has been quoted as 1.2%-9.9%, with Graves' disease as its most common cause. Radioiodine-131 (RAI) therapy of hyperthyroidism recently commenced in two government hospitals in Ghana and Nigeria. This is a retrospective analysis of consecutive patients treated with RAI for primary hyperthyroidism at the National Centre for Radiotherapy and Nuclear Medicine (NCRNM) from 2008-2013, and in the University College Hospital (UCH) from 2006-2013. Cure was defined as euthyroidism or hypothyroidism occurring at 6 months post-RAI. Data were analysed using SPSS version 21 and Epi Info version, categorical data were evaluated with the Chi-square test and Fisher's exact test. 94 patients were studied, aged 20-74 years; 78 were females, and 16 were males. 38 were Ghanaian and 56 Nigerian. The presence of thyroid-associated ophthalmopathy (TAO) made cure less likely (χ2 P = 0.006, odds ratio = 0.118; 95% confidence interval, 0.027-0.518). Other factors assessed proved to be insignificant. Our findings suggest that hyperthyroid patients with TAO will benefit from a higher RAI dose than their counterparts without TAO.

Keywords

Goitre - hyperthyroidism - nuclear medicine - radioiodine - West Africa


Publication History

Article published online:
19 May 2022

© 2016. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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