Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

Reyhan Köroglu; İsmail Köksal; Fikri Şimşek; Fatma Gezer; Ersoy Kekilli; Bülent Ünal

doi:10.4103/1450-1147.215485

World Journal of Nuclear Medicine, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · World J Nucl Med 2017; 16(04): 275-280
DOI: 10.4103/1450-1147.215485

Original article

Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

Reyhan Köroglu

Department of Nuclear Medicine, Faculty of Medicine, Karabuk University, Karabuk

,

İsmail Köksal

¹Department of Nuclear Medicine, Malatya State Hospital, Malatya

,

Fikri Şimşek

²Department of Nuclear Medicine, Elazig Education and Research Hospital, Elazig

,

Fatma Gezer

³Department of Anesthesiology and Reanimation, Education and Research Hospital, Yıldırım Beyazıt University, Ankara

,

Ersoy Kekilli

⁴Department of Nuclear Medicine, Faculty of Medicine, Inonu University, Malatya

,

Bülent Ünal

⁵Department of Oncologic Surgery, Faculty of Medicine, Inonu University, Malatya

› Institutsangaben

Abstract

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It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of ¹⁸F-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1^st h (PET-1) and in the 2^nd h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2, , RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely.

Keywords

Breast cancer - prognostic factors - semiquantitative positron emission tomography parameters

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