Treatment response evaluation using Yttrium-90 in patients with rheumatoid arthritis of knee joint

For radiosynovectomy, we have measured the retention time of yttrium-90 (⁹⁰Y) hydroxyapatite (particle size 1–10 μm) within the knee joint space and evaluated the treatment responses in knees with rheumatoid arthritis. Radioactive measurements in the region of knee after injection of ⁹⁰Y hydroxyapatite into the joint space were made with a single prove system designed to monitor radioactivity and showed retention of ⁹⁰Y in the knee ranged 76.6% ±5.4% after 4 days of injection. The clinical improvements in rheumatoid arthritis of knee joint with steinbroker Stages I and II were increased as time goes by, the improvement ratio is in 72% at 6^th months and 76% at 12^th months after injection of ⁹⁰Y 185 MBq (5 mCi) per joint.

Keywords

Knee joint - radiosynovectomy - yttrium-90 hydroxyapatite