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CC BY-NC-ND 4.0 · Asian J Neurosurg 2016; 11(04): 407-411
DOI: 10.4103/1793-5482.153500
ORIGINAL ARTICLE

Ganglioglioma: Single-institutional experience of 24 cases with review of literature

Vivek Tandon
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
,
Sumit Bansal
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
,
P Chandra
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
,
Ashish Suri
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
,
Manjari Tripathi
1   Department of Neurology, All India Institute of Medical Sciences, New Delhi
,
Mehar Sharma
2   Department of Neuropathology, All India Institute of Medical Sciences, New Delhi
,
Avijit Sarkari
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
,
Ashok Mahapatra
Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi
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Background: Ganglioglioma is a common seizure associated tumor. The goal of this study was to observe the postoperative outcome in patients with gangliogliomas. Material and Methods: A total 24 patients with gangliogliomas who underwent surgery at our institute from 2008 to 2011 were included. There were 13 males (54%) in our study. A retrospective analysis for the demographic profile, surgery and outcome was performed using STATA software. Literature on this subject was also reviewed, MEDLINE and PUBMED databases were searched. Observations: Sixteen patients presented with signs and symptoms of raised intracranial pressure and 12 patients had seizure disorder. Average age at surgery was 20 years (range 7-50 years). Twelve each were located in the temporal lobe and extra-temporal location. Intra-operative electrocorticography (ECoG) alone in three and image guidance alone were used in two patients, respectively. Both ECoG and image guidance were used in one patient and none of them was used in 18 patients. Gross total resection was achieved in 17 patients. After a mean follow-up of 1.6 years (range 3 months to 2.5 years), out of 12 patients with preoperative seizures, 10 (83.3%) were seizure free (Engel class-I) and 2 (16.6%) belonged to Engel class-II. None of the factors, including age at surgery, seizure duration prior to surgery, type of seizures, use of intra-operative ECoG and image guidance, extent of tumor resection, and surgical strategy proved to have significant correlation with postoperative seizure outcome. Conclusions: Surgical treatment is effective and safe for patients with gangliogliomas. Neither intra-operative ECoG nor image guidance necessarily leads to better seizure control, although they are useful adjunct for achieving safe and complete tumor resection.

Key-words:

Epilepsy surgery - ganglioglioma - intra-operative electrocorticography - neuronavigation


Publication History

Article published online:
20 September 2022

© 2016. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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