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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2016; 08(03): 73-80
DOI: 10.4103/1947-489X.210220
Article

Effects of simvastatin and omega 3-fatty acids on blood pressure, plasma lipid profiles, liver and renal function in type 2 diabetes

Ragab Roaeid
1   Department of Internal Medicine, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Fadya Menesi
2   Department of Internal Medicine (Nephrology), Faculty of Medicine, University of Omar El Mukhtar, Al Baidha, Libya
,
Safa Elbadri
3   Department of Pharmacology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Esam Denna
4   Department of Physiology, Faculty of Public Health, University of Benghazi, Benghazi, Libya
,
Ghazala Othman
3   Department of Pharmacology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Mustafa Younis
5   Department of Biochemistry, Faculty of Public Health, University of Benghazi, Benghazi, Libya
,
Faraj El-Shari
5   Department of Biochemistry, Faculty of Public Health, University of Benghazi, Benghazi, Libya
,
Abdulkader El Debani
3   Department of Pharmacology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Awad Abdellatif
3   Department of Pharmacology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
,
Saleh Meghil
1   Department of Internal Medicine, Faculty of Medicine, University of Benghazi, Benghazi, Libya
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A group of patients with and hyperlipidemia were divided into male and female groups and further subdivided into 3 groups. These groups received, either simvastatin (20 mg daily), Omega3-fatty acid (2g/day), or both. The blood pressure and lipid profile were measured before and after 4 weeks of treatment. Our data showed that treatment with simvastatin did not produce significant effect on blood pressure, however the blood pressure was significantly reduced in patients received omega 3-fatty acid or simvastatin plus omega3-fatty acid. The total cholesterol (TC), triglycerides (TG), and low density lipoprotein (LDL) significantly decreased in all treated groups. The high density lipoprotein (HDL) significantly increased in all treated groups except in the group of males receiving simvastatin. Alanine transaminase (ALT) increased significantly in female and male groups receiving simvastatin, but significantly decreased in same groups receiving omega 3-fatty acid and in the males receiving simvastatin plus omega3-fatty acid. The aspartate transaminase (AST) levels significantly decreased in all treated groups except in the female group given omega3-fatty acid. The alkaline phosphatase (ALP) significantly increased only in the groups given simvastatin alone. The levels of urea and creatinine were not affected in all groups. In our prospective study we found that simvastatin decreased TC, TG and LDL, and resulted in elevation of liver transaminases. Omega3- fatty acid alone or in combination with simvastatin has similar effect on lipid profile and it significantly reduces blood pressure without affecting liver or renal function.

Key-words:

Type 2 diabetes mellitus - Simvastatin - Omega-3 fatty acid - ALT - AST - ALP - Blood pressure


Publication History

Received: 07 December 2015

Accepted: 28 April 2016

Article published online:
07 July 2022

© 2016. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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