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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2013; 05(04): 196-205
DOI: 10.4103/1947-489X.210545
Article

The role of angiogenic biomarkers in gastrointestinal cancer

Sahar El-Deek
1   Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Naglaa Idriss
1   Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Randa Hana
1   Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Madleen Abdou
2   Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Doaa Maksemose
3   South Cancer Institute, Assiut University, Assiut, Egypt
,
Madeha Zakhary
1   Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
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Background: Angiogenesis is a key issue in the carcinogenesis progression. Gastrointestinal tract (GIT) cancer is a multi-stage disease, multifaceted, concerning convention of different signaling cascades. Abnormal angiogenesis have been related to pathogenesis of tumor. Objectives: We hypothesized inter-relationships between indices of angiogenesis biomarkers across the spectrum of GIT cancer and its relation to the pathogenesis and prognosis of the diseases. We also evaluated the consequence of estimating these indices in untimely tumor recognition. Methods: Forty patients were studied and divided into two groups: Group 1 (n=30) with GIT cancer and group 2 (n=10) with benign lesion. The cancer group subdivided into patients with gastric cancer (n= 12) and patients with colorectal cancer (n=18). 20 healthy controls (C) were involved in the study. Serum levels of all biochemical indices were estimated. Results: Significantly high serum levels of studied angiogenic biomarkers were detected in patients with GIT cancer compared to C and benign group (p<0.000l and p<0.001 for each respectively). Their levels being significantly higher in late stage of the disease versus early stage and in patients with high tumor burden versus patients with low tumor burden with the exception of Cathpsin-B and HA that showing no significant difference. Positive Significant correlations was present between all indices in cancer groups (p<0.001). Also, there was significant positive correlations between these biomarkers and stage of the tumor (p<0.01). Conclusions: There was a gradation in angiogenesis biomarkers in patients with GIT cancer which related to stage and size of the tumors. This may reflect the relative roles of these biomarkers in the biology of GIT cancer. Their estimation may have implications for our understanding of the pathphysiology of tumor, play a novel beneficial roles in early tumor detection and targeted tumor therapy by using antangiogenic therapy

Key-words:

Angiogenesis - Gastric cancer and Colorectal cancer.


Publication History

Received: 31 December 2012

Accepted: 09 March 2013

Article published online:
07 July 2022

© 2013. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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