Fluoride levels and osteosarcoma

Simmi Kharb; Ravindra Sandhu; Zile Singh Kundu

doi:10.4103/2278-330X.103717

South Asian Journal of Cancer, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · South Asian J Cancer 2012; 01(02): 76-77
DOI: 10.4103/2278-330X.103717

Original Article

Fluoride levels and osteosarcoma

Simmi Kharb

Departments of Biochemistry, Pt.BDS PGIMS, Rohtak, India

,

Ravindra Sandhu

Departments of Biochemistry, Pt.BDS PGIMS, Rohtak, India

,

Zile Singh Kundu

Departments of Orthopedics, Pt.BDS PGIMS, Rohtak, India

› Institutsangaben

Abstract

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Abstract

Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. Settings and Design: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). Materials and Methods: Serum and drinking water fluoride levels were estimated by ion selective electrode. Statistical analysis used: The data were computed as mean ± SD and Student’s t test was applied. Results: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P < 0.05, P < 0.001, respectively). Conclusions: These results suggest a link between fluoride exposure and osteosarcoma.

Key words

Fluoride - osteosarcoma - serum - water

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Referenzen

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