CC BY-NC-ND 4.0 · South Asian J Cancer 2013; 02(01): 2
DOI: 10.4103/2278-330X.105858
Case Report

Squamous cell carcinoma lung: Presented with bilateral lower limb deep venous thrombosis with gangrene formation

Kaushik Saha
Department of Pulmonary Medicine, Burdwan Medical College, Burdwan, West Bengal
,
Amitabha Sengupta
Department of Pulmonary Medicine, NRS Medical College and Hospital, Kolkata, West Bengal
,
Anupam Patra
Department of Pulmonary Medicine, NRS Medical College and Hospital, Kolkata, West Bengal
,
Debraj Jash
Department of Pulmonary Medicine, NRS Medical College and Hospital, Kolkata, West Bengal
› Institutsangaben
Source of Support: Nill.

Abstract

Bilateral venous thrombosis due to underlying malignancy is a rare entity. It is worthy to search for malignancy in patients of bilateral venous gangrene. Our patient presented with severe bilateral leg pain as a result of venous gangrene. There was associated left sided massive pleural effusion with scalp nodule. Fine needle aspiration cytology of scalp nodule revealed metastatic squamous cell carcinoma and fiber optic bronchoscopy guided biopsy from growth at left upper lobe bronchus confirmed the case as squamous cell carcinoma lung. It was rare for squamous cell carcinoma lung to present as bilateral venous gangrene with anticardiolipin antibody negative.



Publikationsverlauf

Artikel online veröffentlicht:
31. Dezember 2020

© 2013. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. https://creativecommons.org/licenses/by-nc-nd/4.0/.

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Lee AY, Levine MN. Venous thromboembolism and cancer: Risks and outcomes. Circulation 2003;107:17-21.
  • 2 Donati MB. Cancer and thrombosis from phlegmasia alba dolens to transgenic mice. Thromb Haemost 1995;74:278-81.
  • 3 Prandoni P, Falanga A, Piccioli A. Cancer and venous thromboembolism. Lancet Oncol 2005;6:401-10.
  • 4 Hopper WC, Evatt BL. The role of activated protein C resistance in the pathogenesis of venous thrombosis. Am J Med Sci 1998;316:120-8.
  • 5 Francis JL, Biggerstaff J, Amirkhosravi A. Hemostasis and malignancy. Semin Thromb Hemost 1998;24:93-109.
  • 6 Yang MH, Fan FS, Chen P, Liu J, Chiou T, Wang W, et al. Venous gangrene in a patient with adenocarcinoma of the lung. Jpn J Clin Oncol 2000;30:276-8.
  • 7 Zuckerman E, Toubi E, Golan TD, Rosenvald-Zuckerman T, Sabo E, Shmuel Z, et al. Increased thrombo-embolic incidence in anticardiolipin positive patients with malignancy. Br J Cancer 1995;72:447-51.
  • 8 Tesselaar ME, Osanto S. Risk of venous thromboembolism in lung cancer. Curr Opin Pulm Med 2007;13:362-7.
  • 9 Wahrenbrock M, Borsig L, Le D, Varki N, Varki A. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest 2003;112:853-62.
  • 10 Starling N, Rao S, Cunningham D, Iveson T, Nicolson M, Coxon F, et al. Thromboembolism in patients with advanced gastroesophageal cancer treated with anthracycline, platinum, and fluoropyrimidine combination chemotherapy: A report from the UK National Cancer Research Institute Upper Gastrointestinal Clinical Studies Group. J Clin Oncol 2009;27:3786-93.
  • 11 Donati MB, Falanga A. Pathogenetic mechanisms of thrombosis in malignancy. Acta Haematol 2001;106:18-24.
  • 12 Heit JA, Silverstein MD, Mohr DN, Petterson TM, O′Fallon WM, Melton LJ 3 rd . Risk factors for deep vein thrombosis and pulmonary embolism: A population-based case-control study. Arch Intern Med 2000;160:809-15.
  • 13 Agnelli G, Verso M. Management of venous thromboembolism in patients with cancer. J Thromb Haemost 2011;9:S316-24.
  • 14 Lee AY. Anticoagulation in the treatment of established venous thromboembolism in patients with cancer. J Clin Oncol 2009;27:4895-901.
  • 15 Putterman C, Tadmor B, Simer L, Caraco Y. Recurrent venous thrombosis as a presenting signs of two primary lung carcinoma-15 years apart. Respir Med 1992;86:521-3.