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CC BY-NC-ND 4.0 · South Asian J Cancer 2016; 05(01): 005-007
DOI: 10.4103/2278-330X.179699
BREAST CANCERS Original Article

The relationship between histologic grades of invasive carcinoma of breast ducts and mast cell infiltration

Ashraf Fakhrjou
Department of Pathology, Hematology and Oncology Research Center, Tabriz Branch, Islamic Azad University, Tabriz
,
Mohammad Naghavi-Behzad
Medical Philosophy and History Research Center, Tabriz Branch, Islamic Azad University, Tabriz
,
Vahid Montazeri
Department of Thoracic Surgery, Tabriz Branch, Islamic Azad University, Tabriz
,
Farid Karkon-Shayan
Liver and Gastrointestinal Disease Research Center, Tabriz Branch, Islamic Azad University, Tabriz
,
Leila Norouzi-Panahi
Department of Midwifery, Tabriz Branch, Islamic Azad University, Tabriz
,
Reza Piri
Students′ Research Committee, Tabriz University of Medical Sciences, Tabriz
› Author Affiliations Source of Support: Nill.
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Abstract

Introduction: Breast carcinoma is the most prevalent tumors among women. Transformation of inflated cells in immune response leads to increase in inflammatory cells such as macrophages, mast cells (MC) and fibroblasts. The aim of this study was to determine the relationship between grades of invasive carcinoma of the breast ducts and MC infiltration around tumoral cells. Methods: During the present study, 75 female patients suffering from invasive ductal carcinoma who underwent surgery or diagnostic biopsy during 2010 and 2013 in Educational-Medical centers of Tabriz University of Medical Sciences, were included in the study. Based on Bloom-Richardson grading system, 25 cases were selected from each grade. To better observe of MCs, samples were stained by Toluidine blue and MCs were counted in 10 40 × 10 fields. Results: The mean age was 47.56 ± 10.84 and the number of MCs was between 6 and 96 and their overall average was 43.01. Average count of MCs in grade 1, 2 and 3 were 15.92 ± 10.07, 45.32 ± 10.47, and 67.8 ± 20.70, respectively. There was a significant relationship between the number of MCs and increase in disease grade (P < 0.001). With increasing grade of malignancy, the number of MCs had grown. No significant relationship was observed between age and grade of disease or age and number of MC. Conclusion: According to obtained results, number of MC around tumoral cells increased significantly with an increase in the grade of disease. In order to treat in thefirst stages of the disease, recognizing primary changes in the stroma of cells could be helpful.

Key words

Breast cancer - histopathological grade - invasive ductal carcinoma - mast cell


Publication History

Article published online:
30 December 2020

© 2016. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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