Chronic myeloid leukemia: In pursuit of perfection

Vishal Jayakar

doi:10.4103/2278-330X.96498

South Asian Journal of Cancer, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · South Asian J Cancer 2012; 01(01): 16-24
DOI: 10.4103/2278-330X.96498

Mini Symposium on CML

Chronic myeloid leukemia: In pursuit of perfection

Vishal Jayakar

Consultant Haemato-Oncologist, Kingston and Royal Marsden Hospitals, London, UK

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Abstract

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Abstract

The resounding success of imatinib (IM) as front line treatment in patients with chronic myeloid leukemia (CML) has certainly made a paradigm shift in the therapeutic algorithm of this disorder. The precise targeting of the BCR-ABL oncogene in CML has entitled it to be the poster child of translational medicine with a well-deserved Oscar ovation from the oncology community. Clinicians are now empowered with first-, second- and third-generation tyrosine kinases, as well as advanced molecular tools to monitor disease and characterize resistance. We have come a long way in successfully managing these patients, but there are still a significant few unmet clinical needs which need addressing and targeting to optimize clinical outcomes. This review focuses on 4 such pertinent and relevant clinical issues, which still need ironing out to fulfill our ambition of achieving ‘perfection’ in this patient cohort.

Key words

Chronic phase chronic myeloid leukemia - cure - tyrosine kinase inhibitor

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Referenzen

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