CC BY-NC-ND 4.0 · South Asian J Cancer 2012; 01(01): 43-47
DOI: 10.4103/2278-330X.96510
Case Report

Thyroid cancer in Gardner’s syndrome: Case report and review of literature

Sachin B. Punatar
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
,
Vanita Noronha
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
,
Amit Joshi
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
,
Kumar Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
› Author Affiliations
Source of Support: Nill.

Abstract

Gardner′s syndrome is a variant of familial adenomatous polyposis. A multitude of extra-colonic manifestations including various endocrine tumors have been associated with this syndrome, the commonest of which is thyroid cancer. Majority of the patients with thyroid cancer and Gardner′s syndrome are females. Here we describe a male patient with Gardner′s syndrome who subsequently developed thyroid cancer.



Publication History

Article published online:
09 November 2020

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  • References

  • 1 Smith WG. Familial multiple polyposis: Research tool for investigating the etiology of carcinoma of the colon? Dis Colon Rectum 1968;11:17-31.
  • 2 Camiel MR, Mulé JE, Alexander LL, Benninghoff DL. Association of Thyroid Carcinoma with Gardner′s Syndrome in Siblings. N Engl J Med 1968;278:1056-8.
  • 3 LaMont JT, Vickery AL Jr. Case 50-1982 - Liver Dysfunction after Total Colectomy for Intestinal Polyposis. N Engl J Med 1982;307:1566-73.
  • 4 Heilman J, Goff JS. Letter to the editor - Case records of the Massachusetts General Hospital (Case no 50- 1982). N Engl J Med 1983;308:906-7.
  • 5 Delamarre J, Capron JP, Armand A, Dupas JL, Deschepper B, Davion T. Thyroid Carcinoma in Two Sisters with Familial Polyposis of the Colon: Case Reports and Review of the Literature. J Clin Gastroenterol 1988;10:659-62.
  • 6 Kelly MD, Hugh TB, Field AS, Fitzsimons R. Carcinoma of the thyroid gland and Gardner′s syndrome. Aust N Z J Surg 1993;63:505-9.
  • 7 Thompson JS, Harned RK, Anderson JC, Hodgson PE. Papillary carcinoma of the thyroid and familial polyposis coli. Dis Colon Rectum 1983;26:583-5.
  • 8 Herrera L, Carrel A, Rao U, Castillo N, Petrelli N. Familial adenomatous polyposis in association with thyroiditis Report of two cases. Dis Colon Rectum 1989;32:893-6.
  • 9 Bell B, Mazzaferri EL. Familial adenomatous polyposis (Gardner′s syndrome) and thyroid carcinoma - A case report and review of the literature. Dig Dis Sci 1993;38:185-90.
  • 10 Plail RO, Bussey HJ, Glazer G, Thomson JP. Adenomatous polyposis: An association with carcinoma of the thyroid. Br J Surg 1987;74:377-80.
  • 11 Schneider NR, Cubilla AL, Chaganti RS. Association of endocrine neoplasia with multiple polyposis of the colon. Cancer 1983;51:1171-5.
  • 12 Smith WG, Kern BB. The nature of the mutation in familial multiple polyposis: Papillary carcinoma of the thyroid, brain tumors and familial multiple polyposis. Dis Colon Rectum 1973;16:264-71.
  • 13 Hamilton SR, Bussey HJ, Mendelsohn G, Diamond MP, Pavlides G, Hutcheon D, et al. Ileal adenomas after colectomy in nine patients with Adenomatous polyposis coli/Gardner′s syndrome. Gastroenterology 1979;77:1252-7.
  • 14 Lee FI, MacKinnon MD. Papillary thyroid carcinoma associated with polyposis coli - A case of Gardner′s syndrome. Am J Gastroenterol 1981;76:138-40.
  • 15 Keshgegian AA, Enterline HT. Gardner′s syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary-follicular adenocarcinoma. Dis Colon Rectum 1978;21:255-60.
  • 16 Reed MW, Quayle AR, Harris SC, Talbot CH. The association between thyroid neoplasia and intestinal polyps. Ann R Coll Surg Engl 1990;72:357-9.
  • 17 Hizawa K, Iida M, Yao T, Aoyagi K, Oohata Y, Mibu R, et al. Association between thyroid cancer of cribriform variant and familial adenomatous polyposis. J Clin Pathol 1996;49:611-3.
  • 18 Piffer S. Gardner′s syndrome and thyroid cancer - A case report and review of the literature. Acta Oncol 1988;27:413-5.
  • 19 Crail HW. Multiple primary malignancies arising in the rectum, brain and thyroid. U S Nav Med Bull 1949;49:123-8.
  • 20 Lockhart-Mummery HE. Intestinal polyposis: The present position. Proc R Soc Med 1967;60:381-8.
  • 21 Alm T, Licznerski G. The intestinal polyposis. Clin Gastroenterol 1973;2:577-602.
  • 22 Van Erpecum KJ, van Berge Henegouwen GP, Meinders AE, Bronkorst FB. Papillary thyroid carcinoma and characteristic pigmented ocular fundus lesions in a patient with Gardner′s syndrome. Neth J Med 1988;32:136.
  • 23 Bulow S, Holm NV, Mellemgaard A. Papillary thyroid carcinoma in Danish patients with familial adenomatous polyposis. Int J Colorect Dis 1988;3:29-31.
  • 24 Harned RK, Buck JL, Olmsted WW, Moser RP, Ros PR. Extracolonic manifestation of familial adenomatous polyposis syndromes. Am J Radiol 1991;156:481-5.
  • 25 Half E, Bercovich D, Rozen P. Familial adenomatous polyposis. Orphanet J Rare Dis 2009;4:22.