Download PDF
CC BY-NC-ND 4.0 · European Journal of General Dentistry 2012; 1(02): 74-77
DOI: 10.4103/2278-9626.103374
Review Article

Role of tissue engineering in dental pulp regeneration

Shruti Sial
Department of Conservative Dentistry, Government Dental College and Hospital, Raipur, Chhattisgarh, India
,
Sunit Kumar Jurel
1   Department of Prosthodontics, Faculty of Dental Sciences, Upgraded KGMC, Lucknow, Uttar Pradesh, India
,
Raghuwar D. Singh
1   Department of Prosthodontics, Faculty of Dental Sciences, Upgraded KGMC, Lucknow, Uttar Pradesh, India
,
Durga S. Gupta
2   Department of Oral and Maxillofacial Surgery, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India
,
Mayank Singh
1   Department of Prosthodontics, Faculty of Dental Sciences, Upgraded KGMC, Lucknow, Uttar Pradesh, India
› Author Affiliations
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

Stem cells constitute the source of differentiated cells for the generation of tissues during development, and for regeneration of tissues that are diseased or injured postnatally. In recent years, stem cell research has grown exponentially owing to the recognition that stem cell-based therapies have the potential to improve the life of patients with conditions that span from Alzheimer′s disease to cardiac ischemia to bone or tooth loss. Growing evidence demonstrates that stem cells are primarily found in niches and that certain tissues contain more stem cells than others. Among these tissues, the dental pulp is considered a rich source of mesenchymal stem cells that are suitable for tissue engineering applications. It is known that dental pulp stem cells have the potential to differentiate into several cell types, including odontoblasts, neural progenitors, osteoblasts, chondrocytes, and adipocytes. The dental pulp stem cells are highly proliferative. Collectively, the multipotency, high proliferation rates, and accessibility make the dental pulp an attractive source of mesenchymal stem cells for tissue regeneration. This review discusses fundamental concepts of stem cell biology and tissue engineering within the context of regenerative dentistry.

Keywords

Apexogenesis - dental pulp stem cells - pulp/dentin tissue regeneration - apexification - pulp revascularization


Publication History

Article published online:
01 November 2021

© 2012. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Saber SE. Tissue engineering in endodontics. J Oral Sci2009;51:495-507.
  • 2 Hargreaves KM, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: What does the future hold? J Endod 2008;34 (7 Suppl):51-6.
  • 3 Shabahang S, Torabinejad M, Boyne PP, Abedi H, McMillan P. A comparative study of root-end induction using osteogenic protein-1, calcium hydroxide, and mineral trioxide aggregate in dogs. J Endod 1999;25:1-5.
  • 4 Murray PE, Garcia-Godoy F. Stem cell responses in tooth regeneration. Stem Cells Dev 2004;13:255-62.
  • 5 Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: Stem cells from human exfoliated deciduous teeth. ProcNatlAcadSci USA 2003;100:5807-12.
  • 6 Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. J Dent Res 2002;81:531-5.
  • 7 Sloan AJ, Waddington RJ. Dental pulp stem cells: What, where, how? Int J Paediatr Dent 2009;19:61-70.
  • 8 Bluteau G, Luder HU, De Bari C, Mitsiadis TA. Stem cells for tooth engineering. Eur Cell Mater 2008;31;16:1-9.
  • 9 Alvarez A, Unda F, Canavate ML, Hilario E. Stem cell and regenerative medicine. CurrStem Cell ResTher2009;4:287-97.
  • 10 Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.ProcNatlAcadSci USA 2000;97:13625-30.
  • 11 Nor JE. Tooth regeneration in operative dentistry. Oper Dent 2006;31:633-42.
  • 12 Papaccio G, Graziano A, Graziano MF, Pirozzi G, Menditti D, d′Aquino R, et al. Long- term cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated osteoblasts: A cell source for tissue repair. J Cell Physiol 2006;208:319-25.
  • 13 Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, et al. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: A pilot study. J Endod2008;34:166-71.
  • 14 Friedlander LT, Cullinan MP, Love RM. Dental stem cells and their potential role in apexogenesis and apexification. IntEndod J 2009:42:955-62.
  • 15 Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • 16 Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res 2005;84:907-12.
  • 17 Rafter M. Apexification: A review. DentTraumatol 2005;21:1-8.
  • 18 Shah N, Logani A, Bhasker U, Aggrawal V. Efficacy of Revascularization to induce Apexification/Apexogensis in infected, nonvital, immature teeth: A Pilot Clinical Study, J Endod 2008;34:919-25.
  • 19 Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. DentTraumatol 2001;17:185-7.
  • 20 Huang GT. Apexification: The beginning of its end. IntEndod J 2009;42:855-66.
  • 21 Andreasen JO, Farik B, Munksgaard EC. Long term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-7.
  • 22 Bakland LK. Endodontic considerations in dental trauma. In: Ingle JI, Bakland LK, editors. Endodontics. 5th ed. Canada:BC Decker Inc; 2002.p. 795-844.
  • 23 Gopikrishna V, Parmeswaran A, Kandaswamy D. Criteria for management of calcific metamorphosis: Review with a case report. Indian J Dent Res 2004;15:54-7.
  • 24 Ohman A. Healing and sensitivity to pain in young replanted human teeth: An experimental, clinical and histological study. OdontolTidskr 1965;73:168-227.
  • 25 Barrett AP, Reade PC. Revascularization of mouse tooth isografts and allografts using autoradiography and carbon perfusion. Arch Oral Boil 1981;26:541-5.
  • 26 Kling M, Cvek M, Mejare I. Rate and predictability of pulp revascularization in therapeutically reimplanted permanent incisors. Endod Dent Traumatol 1986;2:83-9.
  • 27 Buurma B, Gu K, Rutherford B. Transplantation of human pulpal and gingival fibroblast attached to synthetic scaffolds. Eur J Oral Sci 1999;107:282-9.
  • 28 Huang GT. A paradigm shift in endodontic management of immature teeth: Conservation of stem cells for regeneration. J Dent 2008;36:379-86.
  • 29 Friedlander LT, Cullinan MP, Love RM. Dental stem cells and their potential role in apexogenesis and apexification. IntEndod J 2009;42:955-62.
  • 30 Chen SC, Marino V, Gronthos S, Bartold PM. Location of putative stem cells in human periodontal ligament. J Periodontal Res 2006;41:547-53.
  • 31 Mooney DJ, Powell C, Piana J, Rutherford B. Engineering dental pulp-like tissues in vitro. BiotechnolProg1996;12:865-68.
  • 32 Gebhardt M, Murray PE, Namerow KN, Kuttler S, Garcia-Godoy F. Cell survival within pulp and periodontal constructs. J Endod 2009;35:63-6.
  • 33 Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod 2008;34:962-9.