European Journal of General Dentistry, Table of Contents CC BY-NC-ND 4.0 · European Journal of General Dentistry 2012; 1(03): 174-177DOI: 10.4103/2278-9626.105382 Original Article In vivo cytotoxicity of injection molded and conventional pressure pack acrylic resin dentures Ali Riza Tunçdemir Department of Prosthodontics, Faculty of Dentistry, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkiye , Ahmet Koç 1 Department of Embriology, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkiye , Serdar Polat Department of Prosthodontics, Faculty of Dentistry, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkiye , H. Önder Gümüş 2 Department of Prosthodontics, Faculty of Dentistry, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkiye , Mehmet Dalkiz Department of Prosthodontics, Faculty of Dentistry, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkiye › Author Affiliations Recommend Article Abstract PDF Download Abstract Context: Acrylic resins are widely used in the fabrication of denture bases and have been shown to be cytotoxic as a result of substances that leach from the resin. Aim: The purpose of this study was to compare the cytotoxicity of the injectionmolded and conventional pressure-pack heat polymerized acrylic base resin systems with evaluation of the micronucleus frequency on the oral mucosa of the participants. Materials and Methods: This study was carried out by examining the 20 patients′ buccal mucosa who begin to use complete dentures that fabricated by different heat polymerized systems. The micronucleus incidence was scored in the buccal epithelial of each patients. Epithelial cells were collected from oral mucosa by a wooden spatula before applying the prosthesis in the mouth, after 1 week and 1 month and they were smeared on to clean microscope glass slides then examined under light microscope. Results: Micronucleus frequency was higher in individuals′ buccal mucosa who used conventional press pack dentures than injection molded heat polymerized groups. There was not statistically significant differences between conventional and injection molded heat polymerized groups (P>0.05). Number of micronucleus at the end of the 1 week was much more than after 1 month for each groups. Conclusion: Complete dentures that fabricated by injection molded denture base materials is less cytotoxic than conventional pressure pack acrylic resin. 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