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CC BY-NC-ND 4.0 · European Journal of General Dentistry 2013; 2(02): 102-108
DOI: 10.4103/2278-9626.112304
Review Article

Periodontal disease and overall health: An update

Prashanth Balakesavan
Department of Periodontology and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Pune, Maharashtra, India
,
Sneha R. Gokhale
1   Department of Periodontology and Implantology, M.A. Rangoonwala College of Dental Sciences and Research Centre, Pune, Maharashtra, India
,
Vijay Deshmukh
Department of Periodontology and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Pune, Maharashtra, India
,
Ray C. Williams
2   Department of Periodontology, Dean of Dental Medicine, Stony Brook University and School of Dental Medicine, Stony Brook, NY 11794, USA
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Abstract

Periodontitis is a chronic inflammatory disease caused by a mixed microbial infection. The disease is a result of a complex interaction between the bacteria and the susceptible host. The host reaction to the microbial flora leads to a release of pro-inflammatory cytokines and a low grade inflammatory response that has an effect on the overall health status of the patient. Periodontitis has been associated with several systemic conditions such as cardiovascular disease, diabetes, adverse pregnancy outcomes and respiratory infections. In recent years, the relationship of periodontitis to overall health has been explored by numerous researchers who have expanded our understanding of periodontal disease as it affects the overall health of human subjects. This article further examines the relationship of periodontitis to overall health and throws a light on recent associations.

Keywords

Anemia - infertility - neoplasms - periodontitis - periodontitis-systemic disease interactions


Publication History

Article published online:
01 November 2021

© 2013. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Mattila K, Nieminen M, Valtonen V, Rasi VP, Kesäniemi YA, Syrjälä SL, et al. Association between dental health and acute myocardial infarction. BMJ 1989;298:779-81.
  • 2 DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. BMJ 1993;306:688-91.
  • 3 Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol 1996;67:1085-93.
  • 4 Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: A two- way relationship. Ann Periodontol 1998;3:52-61.
  • 5 Taylor GW, Borgnakke WS. Periodontal disease: Associations with diabetes, glycemic control and complications. Oral Dis 2008;14:191-203.
  • 6 Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 1996;67:1103-13.
  • 7 Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol 1999;70:793-802.
  • 8 Graves D. Cytokines that promote periodontal tissue destruction. J Periodontol 2008;79:1585-91.
  • 9 Ritchie CS. Obesity and Periodontal disease. Periodontol 2000 2007;44:154-63.
  • 10 Preus H, Khanifam P, Koltveit K, Mork C, Gjermo P. Periodontitis in psoriasis patients-A blinded, case controlled study. Acta Odonto Scand 2010;68:165-70.
  • 11 Bartold PM, Marshall RI, Haynes DR. Periodontitis and Rheumatoid Arthritis: A review.J Periodontol 2005;76:2066-74.
  • 12 Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. Sperm Morphology, Motility, and Concentration in Fertile and Infertile Men. N Engl J Med 2001;345:1388-93.
  • 13 Bieniek KW, Riedel HH. Bacterial foci in the teeth, oral cavity, and jaw: Secondary effects (remote action) of bacterial colonies with respect to bacteriospermia and subfertility in male. Andrologia 1993;25:159-62.
  • 14 Naz RK, Kaplan P. Increased levels of interleukin-6 in seminal plasma of infertile men. J Andrology 1994;15:220-7.
  • 15 Huleihel M, Lunenfeld E, Levy A, Potashnik G, Glezerman M. Distinct expression levels of cytokines and soluble cytokine receptors in seminal plasma of fertile and infertile men. Fertil Steril 1996;66:135-9.
  • 16 Camejo MI, Segnini A, Proverbio F. Interleukin-6 (IL-6) in seminal plasma of infertile men, and lipid peroxidation of their sperm. Arch Androl 2001;47:97-101.
  • 17 Matalliotakis IM, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G. Increased IL- 18 levels in seminal plasma of infertile men with genital tract infections. Am J Reprod Immunol 2006;55:428-33.
  • 18 Kavoussi SK, West BT, Taylor GW, Lebovic DI. Periodontal disease and endometriosis: Analysis of the National Health and Nutrition Examination Survey. Fertil Steril 2009;91:335-42.
  • 19 Klinger A, Hain B, Yaffe H, Schonberger O. Periodontal status of males attending an in vitro fertilization clinic. J Clin Peridontol 2011;38:542-6.
  • 20 Newnham JP, Newnham IA, Ball CM, Wright M, Pennell C, Jonathan S, et al. T reatment of Periodontal Disease During Pregnancy. Obstet Gynecol 2009;114:1239-48.
  • 21 McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr 2009;12:444-54.
  • 22 Lee GR. The anemia of chronic disease. Semin Hematol 1983;20:61-80.
  • 23 Beutler E. The common anemias. J Am Med Asso 1988;259:2433-7.
  • 24 Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. J Am Soc Hematol 1992;80:1639-47.
  • 25 Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
  • 26 Cartwright GE. The anemia of chronic disorders. Semin Hematol 1966;3:351-75.
  • 27 Lainson PA, Brady PP, Fraleigh CM. Anemia, a systemic cause of periodontal disease? J Periodontol 1968;39:35-8.
  • 28 Chawla TN, Kapoor KK, Teotia SP, Singh NK. Anaemia and periodontal disease-a correlative study. J Indian Dent Asso 1971;43:67-78.
  • 29 Siegel EH. Total erythrocyte, leucocyte and differential white cell counts of blood inchronic periodontal disease. J Dent Res 1945;24:270-1.
  • 30 Hutter JW, Van der Velden U, Varoufaki A, Huffels RA, Hoek FJ, Loos BG. Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects. J Clin Periodontol 2001;28:930-6.
  • 31 Gokhale S, Sumanth S, Padhye A. Evaluation of blood parameters in patients with Chronic Periodontitis for Signs of Anemia. J Periodontol 2010;81:1202-6.
  • 32 Pradeep AR, Sharma A, Raju AP. Anemia of Chronic Disease and Chronic Periodontitis: Does Periodontal Therapy have an Effect on Anemic Status? J Periodontol 2011;82:388-94.
  • 33 Proctor R, Kumar N, Stein A, Moles D, Porter S. Oral and dental aspects of chronic renal failure. J Dent Res 2005;84:199-208.
  • 34 Borawski J, Wilczyñska-Borawska M, Stokowska W, My?liwiec M. The periodontal status of predialysis chronic kidney disease and maintenance dialysis patients. Nephrol Dial Transplant 2007;22:457-64.
  • 35 Fisher MA, Taylor GW, West BT, McCarthy ET. Bidirectional relationship between chronic kidney and periodontal disease: A study using structural equation modeling. Kidney Int 2011;79:347-55.
  • 36 Fisher MA, Taylor GW, Papapanou PN, Rahman M, Debanne SM. Clinical and serologic markers of periodontal infection and chronic kidney disease. J Periodontol 2008;79:1670-8.
  • 37 Phipps KR, Stevens VJ. Relative contribution of caries and periodontal disease in adult tooth loss for an HMO dental population. J Public Health Dent 1995;55:250-2.
  • 38 Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Papapanou PN, et al. Relationship between periodontal disease, tooth loss, and carotid artery plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Stroke 2003;34:2120-5.
  • 39 Fisher MA, Taylor GW, Shelton BJ, Jamerson KA, Rahman M, Ojo AO, et al. Periodontal disease and other nontraditional risk factors for CKD. Am J Kidney Dis 2008;51:45-52.
  • 40 Meyer MS, Joshipura KJ, Giovannucci E, Michaud DS. A review of the relationship between tooth loss, periodontal disease and cancer. Cancer Causes Control 2008;19:895-907.
  • 41 Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol 2005;76:406-10.
  • 42 Rosenquist K, Wennerberg J, Schildt EB, Bladstrom A, Goran Hansson B, Andersson G. Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. Acta Otolaryngologica 2005;125:1327-36.
  • 43 Tezal M, Sullivan MA, Reid ME, Marshall JR, Hyland A, Loree T, et al. Chronic periodontitis and the risk of tongue cancer. Arch Otolaryngol Head Neck Surg 2007;133:450-4.
  • 44 Rezende CP, Ramos MB, Daguíla CH, Dedivitis RA, Rapoport A. Oral health changes in with oral and oropharyngeal cancer. Braz J Otorhinolaryngol 2008;74:596-600.
  • 45 Michaud DS, Liu Y, Meyer M, Giovannucci E, Joshipura K. Periodontal disease, tooth loss, and cancer risk in male health professionals: A prospective cohort study. Lancet Oncol 2008;9:550-8.
  • 46 Hujoel PP, Drangsholt M, Spiekerman C, Weiss NS. An exploration of the periodontitis-cancer association. Ann Epidemiol 2003;13:312-6.
  • 47 Tu YK, Galobardes B, Smith GD, McCarron P, Jeffreys M, Gilthorpe MS. Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort. Heart 2007;93:1098-103.
  • 48 Loe H. Oral hygiene in the prevention of caries and periodontal disease. Int Dent J 2000;50:129-39.
  • 49 Stolzenberg-Solomon RZ, Dodd KW, Blaser MJ, Virtamo J, Taylor PR, Albanes D. Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr 2003;78:176-181.
  • 50 Nair J, Ohshima H, Nair UJ, Bartsch H. Endogenous formation of nitrosamines and oxidative DNA-damaging agents in tobacco users. Crit Rev Toxicol 1996;26:149-61.
  • 51 Ziebarth D, Spiegelhalder B, Bartsch H. N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastrointestinal tract, including Helicobacter pylori. Carcinogenesis 1997;18:383-9.
  • 52 Crespi M, Ohshima H, Ramazzotti V, Muñoz N, Grassi A, Casale V, et al. Intragastric nitrosation and precancerous lesions of the gastrointestinal tract: Testing of an etiological hypothesis. IARC Sci Publ 1987;84:511-7.
  • 53 Thompson M. Aetiological factors in gastrointestinal carcinogenesis. Scand J Gastroenterol 1984;104:77-89.
  • 54 Reed PI, Smith PL, Haines K, House FR, Walters CL. Gastric juice N-nitrosamines in health and gastroduodenal disease. Lancet 1981;2:550-2.
  • 55 Ruddell WS, Bone ES, Hill MJ, Blendis LM, Walters CL. Gastricjuice nitrite. A risk factor for cancer in the hypochlorhydric stomach? Lancet 1976;2:1037-9.
  • 56 Tannenbaum SR, Wishnok JS, Leaf CD. Inhibition of nitrosamine formation by ascorbic acid. Am J Clin Nutr 1991;53:247-50.
  • 57 Michaud DS, Joshipura K, Giovannucci E, Fuchs CS. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Nat Cancer Inst 2007;17:171-5.
  • 58 Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Taylor PR, Mark SD. Tooth loss is associated with increased risk of total death, and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol 2005;34:467-74.
  • 59 Tramini P, Montal S, Valcarcel J. Tooth loss and associated factors in long-term institutionalized elderly patients. Gerodontology 2007;24:196-203.
  • 60 Söder B, Jin LJ, Klinge B, Söder PO. Periodontitis and premature death: A 16-year longitudinal study in a Swedish urban population J Periodontal Res 2007;42:361-6.
  • 61 Ajwani S, Matilla KJ, Tilvis R, Ainamo A. Periodontal disease and mortality in an aged population. Spec Care Dentist 2003;23:125-30.