An unusual case of osmotic demyelination syndrome without electrolyte changes in a patient with diabetes

Shrikant S. Kote; Ankur Khandelwal; Deba G. Pathak; Rupankar Nath

doi:10.4103/2348-0548.182335

Journal of Neuroanaesthesiology and Critical Care, Inhaltsverzeichnis

CC-BY-NC-ND 4.0 · J Neuroanaesth Crit Care 2016; 03(02): 145-148
DOI: 10.4103/2348-0548.182335

Case Report

Thieme Medical and Scientific Publishers Private Ltd.

An unusual case of osmotic demyelination syndrome without electrolyte changes in a patient with diabetes

Shrikant S. Kote

Department of Anaesthesia and Critical Care, Silchar Medical College, Silchar, Assam

,

Ankur Khandelwal

¹Institute of Liver and Biliary Sciences, New Delhi, India

,

Deba G. Pathak

Department of Anaesthesia and Critical Care, Silchar Medical College, Silchar, Assam

,

Rupankar Nath

Department of Anaesthesia and Critical Care, Silchar Medical College, Silchar, Assam

› Institutsangaben

Abstract

Central pontine myelinolysis (CPM) is a demyelinating disease of the pons which is also associated with the demyelination of extrapontine areas of the central nervous system. Although the aetiology and pathogenesis are unclear, CPM is usually associated with hyponatremia or its rapid correction. Malnutrition and chronic alcoholism are also the common underlying conditions. Herein, we report a rare presentation of ODS, secondary to hyperosmolar hyperglycaemic state. We observed a 37-year-old female with diabetes type 1 and hypertension who presented with ataxia, dysarthria and pseudobulbar effect which evolved over a duration of few weeks at home with no evidence of hyponatremia or its rapid correction and no history of alcohol abuse or malnutrition.

Keywords

Central pontine myelinolysis - diabetes mellitus - extrapontine myelinolysis - hyperosmolar hyperglycaemic state - osmotic demyelination syndrome

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Referenzen

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