Download PDF
CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(01): 075-081
DOI: 10.4103/JLP.JLP_117_18
Original Article

Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

Neha Gupta
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Mahima Yadav
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Vikas Gupta
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Deepshikha Chaudhary
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Shashikant C. U. Patne
Department of Pathology, Homi Bhabha Cancer Hospital (A unit of Tata Memorial Centre, Mumbai), Varanasi, Uttar Pradesh, India
› Author Affiliations Financial support and sponsorship: Nil
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India.

MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others.

RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively.

CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

Key words

Gynecologic malignancy - tumor markers - World Health Organization classification


Publication History

Received: 09 September 2018

Accepted: 28 December 2018

Article published online:
06 April 2020

© 2019.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Changing trends in incidence of ovarian cancer – The Indian scenario. Asian Pac J Cancer Prev 2009;10:1025-30.
  • 2 Sankaranarayanan R, Ferlay J. Worldwide burden of gynaecological cancer: The size of the problem. Best Pract Res Clin Obstet Gynaecol 2006;20:207-25.
  • 3 Forae GD, Aligbe JU. A histopathological overview of ovarian lesions in Benin City, Nigeria: How common are the functional cysts? Int J Med Public Health 2014;4:265-8.
  • 4 Chen VW, Ruiz B, Killeen JL, Cote TR, Wu XC, Correa CN. Pathology and classification of ovarian tumours. North American Association of Central Cancer Registries. Cancer Suppl 2003;97:2631-42.
  • 5 Hauptmann S, Friedrich K, Redline R, Avril S. Ovarian borderline tumors in the 2014 WHO classification: Evolving concepts and diagnostic criteria. Virchows Arch 2017;470:125-42.
  • 6 Garg N, Anand AS, Annigeri C. Study of histomorphological spectrum of ovarian tumours. Int J Med Health Res 2017;3:12-20.
  • 7 Patil RK, Bhandari BJ, Kittur SK, Haravi RM, Aruna S, Jadhav MN. Histomorphological study of ovarian tumours at a tertiary care centre. Ann Pathol Lab Med 2017;4:A638-45.
  • 8 Sanjeev N, Anjali S, Shrikant N, Rahul K. Spectrum of ovarian tumours – A five year study. J Pathol Nepal 2017;7:1180-3.
  • 9 Kanpurwala SH, Chavan SM, Agrawal S. A study of clinicomorphological profile of ovarian tumours in Western India. J Med Sci Clin Res 2016;4:15040-7.
  • 10 Malli M, Vyas B, Gupta S, Desai H. A histological study of ovarian tumours in different age groups. Int J Med Sci Public Health 2014;3:338-41.
  • 11 Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res 2015;6:107-11.
  • 12 Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of Eastern India. J Can Res Ther 2011;7:433-7.
  • 13 Modepalli N, Venugopal SB. Clinicopathological study of surface epithelial tumours of the ovary: An institutional study. J Clin Diagn Res 2016;10:EC01-4.
  • 14 Manoja V, Pramood M, Jyothi V, Chandrashekar KP. Clinicopathological study of ovarian tumours: A 2-year study. Int J Sci Stud 2017;5:300-5.
  • 15 Kuladeepa AV, Muddegowda PH, Lingegowda JB, Doddikoppad MM, Basavaraja PK, Hiremath SS. Histomorphological study of 134 primary ovarian tumors. Adv Lab Med Int 2011;1:69-82.
  • 16 Davis J, Chatterjee T, Abuhantesh A, Meller J, Nirgiotis J. Mature cystic teratoma in a 2 year old: A case report. SM J Case Rep 2017;3:1051.
  • 17 Deodhar KK, Suryawanshi P, Shah M, Rekhi B, Chinoy RF. Immature teratoma of the ovary: A clinicopathological study of 28 cases. Indian J Pathol Microbiol 2011;54:730-5.