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CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(04): 443-447
DOI: 10.4103/JLP.JLP_13_18
Original Article

Coinfection of chikungunya and dengue viruses: A serological study from North Western region of Punjab, India

Maninder Kaur
Department of Microbiology, GMC, Amritsar, Punjab, India
,
Kanwardeep Singh
Department of Microbiology, GMC, Amritsar, Punjab, India
,
Shailpreet K Sidhu
Department of Microbiology, GMC, Amritsar, Punjab, India
,
Pushpa Devi
Department of Microbiology, GMC, Amritsar, Punjab, India
,
Manpreet Kaur
Virology Research and Diagnostic Laboratory, GMC, Amritsar, Punjab, India
,
Sapna Soneja
Department of Microbiology, GMC, Amritsar, Punjab, India
,
Nacchartarjit Singh
Virology Research and Diagnostic Laboratory, GMC, Amritsar, Punjab, India
› Institutsangaben Financial support and sponsorship Financial support was provided by Department of Health Research (DHR), Ministry of Health and family Welfare and ICMR under Viral Research and diagnostic laboratory Project.
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ABSTRACT

INTRODUCTION: Dengue and chikungunya (CHIK) infections appear to be increasing in all parts of India. Aedes aegypti mosquitoes are common vectors for dengue virus (DENV) and CHIK virus (CHIKV). In areas where both viruses cocirculate, they can be transmitted together. There are very few studies discussing the dengue-chik coinfection from Punjab region of India. The present study was undertaken to study the clinical features of dengue–CHIK coinfection and compare with monoinfection.

MATERIALS AND METHODS: IgM antibody capture (MAC) ELISA for dengue IgM and CHIK IgM and ELISA for nonstructural protein 1 antigen was performed on serum samples obtained from suspected patients.

RESULTS: Out of total 3160 samples from suspected patients for dengue infection, 2178 (68.92%) samples were positive for DENV while CHIK IgM antibodies were positive in 127 patients out of the total suspected 373 cases (34.04%). In addition to this, 283 samples were tested for both viruses, out of which 27 sera were positive (9.54%) for coinfection of dengue and CHIK. The comparison of signs and symptoms showed that the coinfected patients had fever in all cases while rash was seen in only 30% cases. Arthralgia (79%) and thrombocytopenia (77%) was seen in significant number of coinfected cases thus revealing overlapping nature of dengue–CHIK coinfection.

Conclusions: Increase in the number of Dengue and Chikungunya infections and their cocirculation is an important public health concern which warrants the implementation of strict control measures.

Keywords

Aedes aegypti - dual infection - ELISA - virology research and diagnostic laboratory


Publikationsverlauf

Eingereicht: 27. Januar 2018

Angenommen: 30. April 2018

Artikel online veröffentlicht:
20. Februar 2020

© 2018.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

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