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CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(03): 234-239
DOI: 10.4103/JLP.JLP_154_18
Original Article

Estimating the burden of enteric fever in Chhattisgarh: A single-center study on culture-positive cases from a newly built tertiary care hospital

Debabrata Dash
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Padma Das
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Anudita Bhargava
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Ujjwala Nitin Gaikwad
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Sanjay Singh Negi
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
,
Archana Wankhede
Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India
› Author Affiliations Financial support and sponsorship Nil
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Abstract

BACKGROUND: Enteric fever is the most common cause of community acquired blood stream infections in under developed and developing countries. The enteric fever is exclusive to humans and transmitted through the faeco-oral route. Though India is an endemic zone for enteric fever, the data is very scarce from Central India. The present study was undertaken to determine the prevalence of enteric fever in this region and to know the antimicrobial susceptibility pattern of the isolated typhoidal Salmonellae.

MATERIAL AND METHOD: We conducted a retrospective analysis of blood culture positive cases of enteric fever over a period of two years (December 2015 to December 2017). All blood cultures submitted for suspected enteric fever and associated symptoms were included in the study. Relevant demographic, clinical and laboratory data were analyzed.

RESULT: A total of 51 cases (3.56%) were of typhoidal Salmonella from a total of 1430 blood culture submission. Salmonella Typhi were 70.5% while Salmonella Paratyphi A were 29.5% of the total isolated Salmonellae. The most vulnerable age group was 10-19years (41.2%). The mean minimum inhibitory concentration of ciprofloxacin for Salmonella Typhi and Salmonella Paratyphi A are 1.20 and 1.97 μg/ml respectively. All the isolates were susceptible to ceftriaxone. Highest isolation was in the July – September quarter (35.3%).

CONCLUSION: There is a high prevalence of the disease which needs urgent focus on safe water, sanitation services and also to establish guidelines for empiric therapy for enteric fever.

Key words

Bloodstream infection - ciprofloxacin resistance - enteric fever - Salmonella


Publication History

Received: 23 November 2018

Accepted: 31 May 2019

Article published online:
07 April 2020

© 2019.

Thieme Medical and Scientific Publishers Private Ltd.
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