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CC BY-NC-ND 4.0 · J Lab Physicians 2017; 9(04): 314-316
DOI: 10.4103/JLP.JLP_161_16
Original Article

High prevalence of clindamycin resistance in Staphylococcus aureus blood culture isolates in São Paulo, Brazil

Felipe S. Lupinacci
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Daniel Bussius
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Felipe Acquesta
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Gustavo Fam
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Raphael Rossi
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Alessandra Navarini
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
,
Marcelo J. Mimica
Department of Pathology, Division of Microbiology, School of Medicine, Santa Casa de São Paulo, São Paulo, Brazil
› Author Affiliations Financial support and sponsorship: Nil.
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Abstract

BACKGROUND: Clindamycin has become an important antimicrobial option for the treatment of Staphylococcus aureus. However, little is known about the current patterns of clindamycin-susceptibility in S. aureus invasive isolates, both in our country and in other developing countries in the world.

AIMS: The aim of this study was to determine the prevalence of constitutive and inducible clindamycin resistance in methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) blood culture isolates in São Paulo, Brazil.

MATERIALS AND METHODS: From July 2011 to June 2012, all S. aureus isolates from blood cultures collected at our hospital were included in the study. Antimicrobial susceptibility testing was performed according to recommendations of the Clinical and Laboratory Standards Institute.

RESULTS: Total prevalence of clindamycin resistance was 68%, including 7.2% with inducible resistance. In MRSA resistance rate was 90.8% whereas in MSSA the rate was 32.7%.

CONCLUSIONS: Our high prevalence of clindamycin resistance highlights the importance of performing D-test in a routine base, as well of maintaining continued surveillance for the prevalence of clindamycin resistance.

Key words

Clindamycin - methicillin resistant Staphylococcus aureus - Staphylococcus aureus


Publication History

Received: 29 November 2016

Accepted: 21 March 2017

Article published online:
19 February 2020

© 2017.

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  • References

  • 1 Mimica MJ, Berezin EN, Carvalho RB. Healthcare associated PVL negative methicillin-resistant Staphylococcus aureus with SCCmec type IV. Pediatr Infect Dis J 2009;28:934.
  • 2 Mimica MJ, Berezin EN, Damaceno N, Carvalho RB. SCCmec type IV, PVL-negative, methicillin-resistant Staphylococcus aureus in cystic fibrosis patients from Brazil. Curr Microbiol 2011;62:388-90.
  • 3 Tarai B, Das P, Kumar D. Recurrent challenges for clinicians: Emergence of methicillin-resistant Staphylococcus aureus, vancomycin resistance, and current treatment options. J Lab Physicians 2013;5:71-8.
  • 4 Cadena J, Sreeramoju P, Nair S, Henao-Martinez A, Jorgensen J, Patterson JE. Clindamycin-resistant methicillin-resistant Staphylococcus aureus: Epidemiologic and molecular characteristics and associated clinical factors. Diagn Microbiol Infect Dis 2012;74:16-21.
  • 5 Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Third Informational Supplement, M100-S23. Wayne, PA: EUA, Clinical and Laboratory Standards Institute; 2013.
  • 6 The European Committee on Antimicrobial Susceptibility Testing. Available from: http://www.eucast.org/clinical_breakpoints/. [Last accessed on 2016 Nov 28].
  • 7 Patra KP, Vanchiere JA, Bocchini JA Jr. Adherence to CLSI recommendations for testing of Staphylococcus aureus isolates in Louisiana hospitals: Report of a clinical failure and results of a questionnaire study. J Clin Microbiol 2011;49:3019-20.
  • 8 Changchien CH, Chen SW, Chen YY, Chu C. Antibiotic susceptibility and genomic variations in Staphylococcus aureus associated with Skin and Soft Tissue Infection (SSTI) disease groups. BMC Infect Dis 2016;16:276.
  • 9 Ghaznavi-Rad E, Neela V, Nor Shamsudin M, Ghasemzadeh Moghaddam H, Tavakol M, van Belkum A, et al. Diversity in the antimicrobial susceptibility patterns of methicillin-resistant Staphylococcus aureus clones. Eur J Clin Microbiol Infect Dis 2012;31:3317-21.
  • 10 McDougal LK, Fosheim GE, Nicholson A, Bulens SN, Limbago BM, Shearer JE, et al. Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. Antimicrob Agents Chemother 2010;54:3804-11.
  • 11 Stevens DL, Ma Y, Salmi DB, McIndoo E, Wallace RJ, Bryant AE. Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus. J Infect Dis 2007;195:202-11.