Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

Abstract

Castleman's disease is a rare disease characterized by unicentric or multicentric enlargement of the lymph node, and it is mostly of the hyaline vascular type. Calcifying fibrous tumor is a neoplasm characterized by large areas of hyalinized collagen with paucicellular areas along with dystrophic calcification and scattered lymphoplasmacytic infiltrates. There are only five case reports to describe an association between these two entities. We report a case of a 38-year-old male with seropositivity for hepatitis B virus presenting with a right-sided cervical swelling. Fine-needle aspiration cytology (FNAC) was done, and a diagnosis of follicular hyperplasia was offered. Biopsy confirmed the diagnosis of Castleman's disease. However, there was associated calcifying fibrous tumor in the lymph node induced by trauma due to FNAC.

Key words

Castleman's disease - hepatitis B virus - lymph node

• References

• 1 Murro D, Agab M, Brickman A, Loew J, Gattuso P. Cytological features of Castleman disease: A review. J Am Soc Cytopathol 2016;5:100-6.
• 2 Dargent JL, Delplace J, Roufosse C, Laget JP, Lespagnard L. Development of a calcifying fibrous pseudotumour within a lesion of Castleman disease, hyaline-vascular subtype. J Clin Pathol 1999;52:547-54.
• 3 Azam M, Husen YA, Pervez S. Calcifying fibrous pseudotumor in association with hyaline vascular type Castleman's disease. Indian J Pathol Microbiol 2009;52:527-9.
• 4 Valladolid G, Weisenberg E, Sundaresan R, Maker AV. Calcifying fibrous tumor of the small intestine associated with Castleman-like lymphadenopathy. J Gastrointest Surg 2014;18:1205-8.
• 5 Ma H, Jiang M, Xiao W. A rare stroma-rich variant of hyaline-vascular Castleman's disease associated with calcifying fibrous pseudotumor. Int J Clin Exp Pathol 2015;8:3362-4.
• 6 Harmankaya İ, Ugras NS, Sekmenli T, Demir F, Köksal Y. Calcified fibrous pseudotumor with Castleman disease. Autops Case Rep 2018;8:e2018033.
• 7 Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995;86:1276-80.
• 8 Yuan XG, Chen FF, Zhu YM, Hu W, Zhao XY, Jin J. High prevalence of hepatitis B virus infection in HIV-negative Castleman's disease. Ann Hematol 2012;91:857-61.
• 9 Rosenthal NS, Abdul-Karim FW. Childhood fibrous tumor with psammoma bodies. Clinicopathologic features in two cases. Arch Pathol Lab Med 1988;112:798-800.
• 10 Zámecník M, Dorociak F, Veselý L. Calcifying fibrous pseudotumor after trauma. Pathol Int 1997;47:812.