Abstract
Plasma cell (PC) neoplasm (PCN) with varied morphology has been described in the literature.
The majority of clonal proliferation of PCs is composed of easily recognizable morphology
in the bone marrow (BM). However, few cases may cause diagnostic complexity, as they
exhibit varied cytological and architectural heterogeneity which may pose problem
in morphological diagnosis and require the use of ancillary techniques like immunohistochemistry
(IHC). We illustrate here two such cases of PCN with varied morphology in BM aspirate,
in the form of clustering/rosetting and multiple clear cytoplasmic vacuoles, respectively,
leading to varied differential diagnosis. However, later, the histopathological features
on BM biopsy findings were relatively characteristic and IHC confirmed the final diagnosis.
The morphological variants documented in both these cases are exceptional and representative
of the various forms of atypical PCs.
Key words
Bone marrow - immunohistochemistry - morphology - plasma cell neoplasm
