Concept and connotation of oxidative stress in preeclampsia

Hayder M. Al-Kuraishy; Ali I. Al-Gareeb; Thabat J. Al-Maiahy

doi:10.4103/JLP.JLP_26_18

Journal of Laboratory Physicians, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(03): 276-282
DOI: 10.4103/JLP.JLP_26_18

Original Article

Concept and connotation of oxidative stress in preeclampsia

Autor*innen

Hayder M. Al-Kuraishy

Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq
Ali I. Al-Gareeb

Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq
Thabat J. Al-Maiahy

Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq

Abstract

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ABSTRACT

BACKGROUND: Preeclampsia (PE) is a systemic pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Free radicals seem to play an important role in the induction of endothelial dysfunction in PE.

AIM: The aim of the present study was to investigate serum levels of nitric oxide (NO), peroxynitrite (ONOO⁻), paraoxonase (PON-1), malondialdehyde (MDA), and lipid profile in preeclamptic patients compared to the women with normal pregnancy.

MATERIALS AND METHODS: A total of 68 pregnant women were recruited. They were divided into two groups - Group A, 40 women were a newly diagnosed with PE and Group B, 28 women with normal pregnancy. Anthropometric measurements including body mass index and blood pressure in accordance with biochemical measurements including NO, ONOO⁻, PON-1, MDA, and lipid profile were done for preeclamptic pregnant women compared to the controls.

RESULTS: Pregnant women with pre-eclampsia illustrated insignificant differences in the age (31.22±2.87) compared to the age of control P > 0.05. There were significant changes in the body mass index (BMI) , type of delivery and smoking status of pregnant women with pre-eclampsia compared to the control P < 0.05. Both systolic and diastolic blood pressures were high in pregnant women with pre-eclampsia compared to the control P < 0.01. PON-1 and NO serum levels were significantly decreased (P < 0.01) while ONOO− and MDA serum levels were significantly increased in PE compared to the women with normal pregnancy.

Conclusions: This study concluded that PE is associated with the augmentation of oxidative stress and reduction of endogenous antioxidant capacity regarding PON-1.

Keywords

Antioxidant capacity - hypertension - nitric oxide - paraoxonase - peroxynitrite - preeclampsia - proteinuria

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Referenzen

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