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CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(02): 162-167
DOI: 10.4103/JLP.JLP_37_17
Original Article

Cluster of differentiation 4+ T-cell counts and human immunodeficiency virus-1 viral load in patients coinfected with hepatitis B virus and hepatitis C virus

Sakshee Gupta
Department of Microbiology, Advance Research Laboratory, SMS Medical College, Jaipur, Rajasthan, India
,
Bharti Malhotra
Department of Microbiology, Advance Research Laboratory, SMS Medical College, Jaipur, Rajasthan, India
,
Jitendra Kumar Tiwari
Department of Microbiology, Advance Research Laboratory, SMS Medical College, Jaipur, Rajasthan, India
,
Prabhu Dayal Khandelwal
Department of Medicine, SMS Medical College, Jaipur, Rajasthan, India
,
Rakesh Kumar Maheshwari
Department of Microbiology, Advance Research Laboratory, SMS Medical College, Jaipur, Rajasthan, India
› Author Affiliations Financial support and sponsorship: This study was financially supported by the Indian Council of Medical research JRF – 2008 (33347) ICMR SRF (33347) and State DST project.
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ABSTRACT

BACKGROUND: Coinfections of human immunodeficiency virus (HIV) with hepatitis viruses may affect the progress of disease and response to therapy.

OBJECTIVES: To study the incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections in HIV–positive patients and their influence on HIV–1 viral load and cluster of differentiation 4+ (CD4+) T–cell counts.

MATERIALS AND METHODS: This pilot study was done on 179 HIV–positive patients attending antiretroviral therapy (ART) centre. Their blood samples were tested for HIV-1 viral load, CD4+ T–cell counts, hepatitis B surface antigen, anti–HCV antibodies, HBV DNA and HCV RNA polymerase chain reaction.

RESULTS: Among the 179 patients, 7.82% (14/179) were coinfected with HBV and 4.46% (8/179) with HCV. Median CD4+ T–cell count of HIV monoinfected patients was 200 cells/µl and viral load was 1.67 log10 copies/µl. Median CD4+ T–cell counts of 193 cells/µl for HBV (P = 0.230) and 197 cells/µl for HCV (P = 0.610) coinfected patients were similar to that of HIV monoinfected patients. Viral load was higher in both HBV and HCV infected patients but statistically significant only for HCV (P = 0.017). Increase in CD4+ T–cell counts and decrease in HIV–1 viral load in coinfected patients on 2 years of ART were lower than that in HIV monoinfected patients.

CONCLUSION: HBV/HCV coinfected HIV patients had similar CD4+ T–cell counts as in HIV monoinfected patients, higher HIV viral load both in chemo–naive patients and in those on ART as compared to HIV monoinfected patients. However, this study needs to be done on a large scale to assess the impact of coinfection on CD4 count and HIV viral load with proper follow–up of patients every 6 months till at least 2 years.

Keywords

Cluster of differentiation 4+ T-cell counts - coinfection - hepatitis B virus - hepatitis C virus - human immunodeficiency virus-1 viral load


Publication History

Received: 08 May 2017

Accepted: 01 August 2017

Article published online:
19 February 2020

© 2018.

Thieme Medical and Scientific Publishers Private Ltd.
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