A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Yusuke Ohba; Minami Yamada-Fujiwara; Tadanori Minagawa; Suguru Watanabe; Yoko Okitsu; Yoshihiko Izumi; Junichi Kameoka; Shinichiro Takahashi

doi:10.4103/JLP.JLP_61_19

Journal of Laboratory Physicians, Table of Contents

CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(04): 382-384
DOI: 10.4103/JLP.JLP_61_19

Case Report

A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Authors

Yusuke Ohba

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Minami Yamada-Fujiwara

Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

Division of Blood Transfusion and Cell Therapy, Tohoku University Hospital, Sendai, Japan
Tadanori Minagawa

Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Suguru Watanabe

Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Yoko Okitsu

Department of Blood Transfusion, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
Yoshihiko Izumi

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Junichi Kameoka

Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Shinichiro Takahashi

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Abstract

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Abstract

An 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/μL), and low levels of red blood cells (2.65 × 10⁶/μL), hemoglobin (10.4 g/dL), and platelets (118,000/μL) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS–U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.

Key words

Chromosome banding - myelodysplastic syndromes - t(10;18)(q26;q21)

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References

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