Download PDF
CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(01): 031-033
DOI: 10.4103/JLP.JLP_91_17
Original Article

Decreasing trend of seroprevalence of hepatic amoebiasis in tertiary care hospital of North India: 2010–2015

Sonu Agrawal
Department of Microbiology, All Institute of Medical Sciences, New Delhi, India
,
Nishant Verma
Department of Microbiology, All Institute of Medical Sciences, New Delhi, India
,
Sowjanya Perumalla
Department of Microbiology, All Institute of Medical Sciences, New Delhi, India
,
Bijay Ranjan Mirdha
Department of Microbiology, All Institute of Medical Sciences, New Delhi, India
› Author Affiliations Financial support and sponsorship: Nil
› Further Information
Also available at
  PDF Download Permissions and Reprints

Abstract

BACKGROUND: Globally, amoebic liver abscess, a common extraintestinal complication of intestinal amoebiasis. Diagnosis of hepatic amoebiasis is based on the detection of anti-Entamoeba histolytica immunoglobulin G (IgG) antibody using enzyme-linked immunosorbent assay (ELISA), because of its technique's relatively higher sensitivity and specificity (90%).

AIM: The aim of the present study was to determine the seroprevalence of hepatic amoebiasis in a referral tertiary care hospital in North India.

MATERIALS AND METHODS: The blood samples were tested specifically for anti-E. histolytica IgG antibody using commercially available ELISA kit (RIDASCREEN® E. histolytica IgG [K1721] kit).

RESULTS: A total of 879 patients (n = 879) were evaluated, of which 78.49% (690/879) were positive for anti-E. histolytica IgG antibody. The seroprevalence rates showed a declining trend from 2010 to 2015 with rates falling from 91.4% to 66.7%. He present a study showed the decreasing trend of seroprevalence of hepatic amoebiasis from 2010 to 2015.

CONCLUSIONS: This decrease may be attributed to several factors such as increase in awareness, improved hygienic practices, use of safe drinking water, better socioeconomic condition, and perhaps early treatment sought for intestinal amoebiasis.

Key words

Hepatic amoebiasis - intestinal amoebiasis - seroprevalence


Publication History

Received: 19 June 2017

Accepted: 23 July 2017

Article published online:
19 February 2020

© 2018.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Dinoop KP, Parija SC, Mandal J, Swaminathan RP, Narayanan P. Comparison of nested-multiplex, Taqman & SYBR Green real-time PCR in diagnosis of amoebic liver abscess in a tertiary health care institute in India. Indian J Med Res 2016;143:49-56.
  • 2 Chacín-Bonilla L. An update on amebiasis. Rev Med Chil 2013;141:609-15.
  • 3 Wuerz T, Kane JB, Boggild AK, Krajden S, Keystone JS, Fuksa M, et al. A review of amoebic liver abscess for clinicians in a nonendemic setting. Can J Gastroenterol 2012;26:729-33.
  • 4 Petri WA, Haque R. Entamoeba histolytica brain abscess. Handb Clin Neurol 2013;114:147-52.
  • 5 Tengku SA, Norhayati M. Public health and clinical importance of amoebiasis in Malaysia: A review. Trop Biomed 2011;28:194-222.
  • 6 Bansal D, Sehgal R, Chawla Y, Malla N, Mahajan RC. Multidrug resistance in amoebiasis patients. Indian J Med Res 2006;124:189-94.
  • 7 Parija SC, Khairnar K. Detection of excretory Entamoeba histolytica DNA in the urine, and detection of E. histolytica DNA and lectin antigen in the liver abscess pus for the diagnosis of amoebic liver abscess. BMC Microbiol 2007;7:41.
  • 8 Haque R, Faruque AS, Hahn P, Lyerly DM, Petri WA Jr. Entamoeba histolytica and Entamoeba dispar infection in children in Bangladesh. J Infect Dis 1997;175:734-6.
  • 9 Parija SC. Progress in the research on diagnosis and vaccines in amebiasis. Trop Parasitol 2011;1:4-8.
  • 10 Dhanalakshmi S, Parija SC. Seroprevalence of Entamoeba histolytica from a tertiary care hospital, South India. Trop Parasitol 2016;6:78-81.
  • 11 Kalkan IH, Daǧli U. What is the most accurate method in the diagnosis of amebic dysentery? Turk J Gastroenterol 2010;21:87-90.
  • 12 Ralston KS, Petri WA Jr. Tissue destruction and invasion by Entamoeba histolytica. Trends Parasitol 2011;27:254-63.
  • 13 Khan AH, Ghosh PK, Das SR. A seroepidemiological survey of amoebiasis in Lucknow. Trop Gastroenterol 1985;6:30-6.
  • 14 Manjula, Mateen MA, Habibullah CM. Seroepidemiology of E. histolytica infection in Hyderabad. Trop Gastroenterol 1986;7:173-7.
  • 15 Jamaiah I, Shekhar KC. Amoebiasis: A 10 year retrospective study at the University Hospital, Kuala Lumpur. Med J Malaysia 1999;54:296-302.
  • 16 Stauffer W, Abd-Alla M, Ravdin JI. Prevalence and incidence of Entamoeba histolytica infection in South Africa and Egypt. Arch Med Res 2006;37:266-9.
  • 17 Caballero-Salcedo A, Viveros-Rogel M, Salvatierra B, Tapia-Conyer R, Sepulveda-Amor J, Gutierrez G, et al. Seroepidemiology of amebiasis in Mexico. Am J Trop Med Hyg 1994;50:412-9.
  • 18 Ansar Ahmed S, Penhale WJ, Talal N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 1985;121:531-51.
  • 19 Nath J, Ghosh SK, Singha B, Paul J. Molecular epidemiology of amoebiasis: A cross-sectional study among North East Indian population. PLoS Negl Trop Dis 2015;9:e0004225.