Subscribe to RSS
DOI: 10.4103/ajm.AJM_123_17
The prevalence of restless leg syndrome among pregnant Saudi women
Financial support and sponsorship Nil.Abstract
Objectives: Restless legs syndrome (RLS) is common among pregnant women, but it has not been documented in pregnant Saudi Arabian women. The main purpose of this study was to estimate the extent of the prevalence of RLS and identify both the associated factors and the associated risk factors among pregnant Saudi women. Methods: A cross-sectional study was conducted among pregnant women visiting obstetric clinics at King Abdulaziz Medical City in Riyadh (KAMC-Riyadh) over the period from June 1 to November 1, 2014. We interviewed the participants and collected demographic data, number of pregnancies, duration of pregnancy, comorbidities, and symptoms of RLS. The diagnosis of RLS is based on the four criteria designated by the International RLS Study Group. Results: The total number of participants enrolled was 517, and the mean age was 30.11 ± 5.42 years. The prevalence of RLS was 21.3% (110/517) (95% confidence interval [CI]: 17.83%-25.06%). RLS symptoms were more common among women in the third trimester (24.1%) compared to the second trimester (14.3%) and first trimester (13.6%), P = 0.043. The stepwise multivariate logistic model identified insomnia (odds ratio [OR]: 3.6, 95% CI: 2.167–6.017, P = 0.001), and poor sleep quality (OR: 4.9, 95% CI: 1.473-16.454, P = 0.010) were associated with RLS. Conclusion: RLS occurs in two of ten pregnant women visiting obstetric clinics at KAMC-Riyadh and is strongly associated with insomnia and poor sleep quality. Studies are needed to explore the causality of these associations.
Keywords
Body mass index - Epworth Sleepiness Scale - excessive daytime sleepiness - Pitts - restless legs syndrome - the International Restless Legs Syndrome Study GroupPublication History
Article published online:
12 August 2021
© 2018. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India
-
References
- 1 Satija P, Ondo WG. Restless legs syndrome: Pathophysiology, diagnosis and treatment. CNS Drugs 2008; 22: 497-518
- 21 Montplaisir J, Boucher D, Poirier G, Lavigne G, Lapierre O, Lespérance P. et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria. Mov Disord 1997; 12: 61-5
- 3 Sethi KD, Mehta SH. A clinical primer on restless legs syndrome: What we know, and what we don't know. Am J Manag Care 2012; 18: S83-8
- 4 Mizuno S, Mihara T, Miyaoka T, Inagaki T, Horiguchi J. CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res 2005; 14: 43-7
- 5 Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep 1998; 21: 371-7
- 6 Winkelman JW. Considering the causes of RLS. Eur J Neurol 2006; 13 Suppl 3: 8-14
- 7 Jhoo JH, Yoon IY, Kim YK, Chung S, Kim JM, Lee SB. et al. Availability of brain serotonin transporters in patients with restless legs syndrome. Neurology 2010; 74: 513-8
- 8 Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 1995; 10: 634-42
- 9 Cho YW, Shin WC, Yun CH, Hong SB, Kim JH, Allen RP. et al. Epidemiology of restless legs syndrome in Korean adults. Sleep 2008; 31: 219-23
- 10 Tunç T, Karadaǧ YS, Doǧulu F, Inan LE. Predisposing factors of restless legs syndrome in pregnancy. Mov Disord 2007; 22: 627-31
- 11 Taşdemir M, Erdoǧan H, Börü UT, Dilaver E, Kumaş A. Epidemiology of restless legs syndrome in Turkish adults on the Western Black Sea coast of Turkey: A door-to-door study in a rural area. Sleep Med 2010; 11: 82-6
- 12 Ghorayeb I, Tison F. Restless legs syndrome epidemiology. Presse Med 2010; 39: 564-70
- 13 Ziaei J, Saadatnia M. Epidemiology of familial and sporadic restless legs syndrome in Iran. Arch Iran Med 2006; 9: 65-7
- 14 Tison F, Crochard A, Léger D, Bouée S, Lainey E, El Hasnaoui A. et al. Epidemiology of restless legs syndrome in French adults: A nationwide survey: The INSTANT study. Neurology 2005; 65: 239-46
- 15 Zucconi M, Ferini-Strambi L. Epidemiology and clinical findings of restless legs syndrome. Sleep Med 2004; 5: 293-9
- 16 Machtey I. Epidemiology of restless legs syndrome. Arch Intern Med 2001; 161: 483-4
- 17 Van De Vijver DA, Walley T, Petri H. Epidemiology of restless legs syndrome as diagnosed in UK primary care. Sleep Med 2004; 5: 435-40
- 18 BaHammam A, Al-shahrani K, Al-zahrani S, Al-shammari A, Al-amri N, Sharif M. et al. The prevalence of restless legs syndrome in adult Saudis attending primary health care. Gen Hosp Psychiatry 2011; 33: 102-6
- 19 Sikandar R, Khealani BA, Wasay M. Predictors of restless legs syndrome in pregnancy: A hospital based cross sectional survey from Pakistan. Sleep Med 2009; 10: 678-8
- 20 Wali SO, Abaalkhail B. Prevalence of restless legs syndrome and associated risk factors among middle-aged Saudi population. Ann Thorac Med 2015; 10: 193-8
- 21 Sherbin N, Ahmed A, Fatani A, Al-Otaibi K, Al-Jahdali F, Ali Y. et al. The prevalence and associated risk factors of restless legs syndrome among Saudi adults. Sleep and Biological Rhythms. Sleep Biol Rhythms 2017; 15: 127-35
- 22 Ismailogullari S, Ozturk A, Mazicioglu M, Serin S, Gultekin M, Aksu M. Restless legs syndrome and pregnancy in Kayseri, Turkey: A hospital based survey. Sleep Biol Rhythms 2010; 8: 137-43
- 23 Minar M, Habanova H, Rusnak I, Planck K, Valkovic P. Prevalence and impact of restless legs syndrome in pregnancy. Neuro Endocrinol Lett 2013; 34: 366-71
- 24 Goodman JD, Brodie C, Ayida GA. Restless leg syndrome in pregnancy. BMJ 1988; 297: 1101-2
- 25 Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T. et al. The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 2003; 26: 673-7
- 26 Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Mollica G. et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med 2004; 5: 305-8
- 27 Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I. et al. Restless legs syndrome and pregnancy. Neurology 2004; 63: 1065-9
- 28 Neau JP, Marion P, Mathis S, Julian A, Godeneche G, Larrieu D. et al. Restless legs syndrome and pregnancy: Follow-up of pregnant women before and after delivery. Eur Neurol 2010; 64: 361-6
- 29 Hensley JG. et al. Leg cramps and restless legs syndrome during pregnancy. J Midwifery Womens Health 2009; 54: 211-8
- 30 Hübner A, Krafft A, Gadient S, Werth E, Zimmermann R, Bassetti CL. et al. Characteristics and determinants of restless legs syndrome in pregnancy: A prospective study. Neurology 2013; 80: 738-42
- 31 Chen PH, Liou KC, Chen CP, Cheng SJ. Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med 2012; 13: 1153-7
- 32 Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP. et al. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med 2003; 4: 121-32
- 33 Johns MW. A new method for measuring daytime sleepiness: The epworth sleepiness scale. Sleep 1991; 14: 540-5
- 34 Ahmed AE, Fatani A, Al-Harbi A, Al-Shimemeri A, Ali YZ, Baharoon S. et al. Validation of the arabic version of the epworth sleepiness scale. J Epidemiol Glob Health 2014; 4: 297-302
- 35 Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index: A new instrument for psychiatric practice and research.. Psychiatry Res 1989; 23: 193-213
- 36 Al-Jahdali HH, Al-Qadhi WA, Khogeer HA, Al-Hejaili FF, Al-Ghamdi SM, Al Sayyari AA. et al. Restless legs syndrome in patients on dialysis. Saudi J Kidney Dis Transpl 2009; 20: 378-85
- 37 Alves DA, Carvalho LB, Morais JF, Prado GF. et al. Restless legs syndrome during pregnancy in Brazilian women. Sleep Med 2010; 11: 1049-54
- 38 Sarberg M, Josefsson A, Wiréhn AB, Svanborg E. Restless legs syndrome during and after pregnancy and its relation to snoring. Acta Obstet Gynecol Scand 2012; 91: 850-5
- 39 Earley CJ, BBarker P, Horská A, Allen RP. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 2006; 7: 458-61
- 40 Ru Y, Pressman EK, Cooper EM, Guillet R, Katzman PJ, Kent TR. et al. Iron deficiency and anemia are prevalent in women with multiple gestations. Am J Clin Nutr 2016; 104: 1052-60
- 41 Bei B, Milgrom J, Ericksen J, Trinder J. et al. Subjective perception of sleep, but not its objective quality, is associated with immediate postpartum mood disturbances in healthy women. Sleep 2010; 33: 531-8
- 42 Dørheim SK, Bondevik GT, Eberhard-Gran M, Bjorvatn B. Sleep and depression in postpartum women: A population-based study. Sleep 2009; 32: 847-55
- 43 Marques M, Bos S, Soares MJ, Maia B, Pereira AT, Valente J. et al. Is insomnia in late pregnancy a risk factor for postpartum depression/depressive symptomatology. Psychiatry Res 2011; 186: 172-80