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DOI: 10.4103/ajm.AJM_198_17
Qat-induced intestinal obstruction: A case series of a new entity
Financial support and sponsorship Nil.Abstract
Background: Qat-induced intestinal obstruction is an acute manifestation of qat chewing which was not described previously in the literature. The aim of this case series is to describe the clinical presentation, the diagnostic and therapeutic measures, and the course of the disease. Methods: This retrospective case series included all patients who presented with qat-induced intestinal obstruction between July 1, 2013, and December 31, 2015. Results: The study included seven patients (five males and two females). The mean age was 41.4 years (22–60 years). All patients presented after 8–12 h of prolonged qat chewing with abdominal pain, severe abdominal distension, and inability to pass stool. Laboratory results were normal apart from slight leukocytosis (<15 × 109/L) in three patients. All patients showed air–fluid levels on the erect abdominal X-ray. The management included intravenous fluids and symptomatic therapy. The symptoms resolved in 1–2 days and the follow-up after 1 week showed no residual complaints. Conclusions: Qat-induced intestinal obstruction is associated with the heavy and prolonged consumption of qat. The presentation mimics acute intestinal obstruction, but the course is benign. Spontaneous resolution with supportive inpatient treatment is the rule.
Publikationsverlauf
Artikel online veröffentlicht:
12. August 2021
© 2018. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Wabe NT. Chemistry, pharmacology, and toxicology of khat (Catha edulis forsk): A review. Addict Health 2011; 3: 137-49
- 2 Nigussie T, Gobena T, Mossie A. et al. Association between khat chewing and gastrointestinal disorders: A cross sectional study. Ethiop J Health Sci 2013; 23: 123-30
- 3 Dhaifalah I, Santavý J. Khat habit and its health effect. A natural amphetamine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2004; 148: 11-5
- 4 El-Setouhy M, Alsanosy RM, Alsharqi A, Ismail AA. Khat dependency and psychophysical symptoms among chewers in Jazan Region, Kingdom of Saudi Arabia. Biomed Res Int 2016; 2016: 2642506
- 5 Yemen Towards Qat Demand Reduction. International Bank for Instruction and Development/World Bank. Contract. 39738-YE; 2007.
- 6 Kennedy JG, Teague J, Rokaw W, Cooney E. A medical evaluation of the use of qat in North Yemen. Soc Sci Med 1983; 17: 783-93
- 7 Teni FS, Surur AS, Hailemariam A, Aye A, Mitiku G, Gurmu AE. et al. Prevalence, reasons, and perceived effects of khat chewing among students of a college in Gondar town, Northwestern Ethiopia: A Cross-sectional study. Ann Med. Health Sci Res 2015; 5: 454-60
- 8 Halbach H. Medical aspects of the chewing of khat leaves. Bull World Health Organ 1972; 47: 21-9
- 9 Toennes SW, Harder S, Schramm M, Niess C, Kauert GF. Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol 2003; 56: 125-30
- 10 Brenneisen R, Geisshüsler S, Schorno X. Metabolism of cathinone to (-)-norephedrine and (-)-norpseudoephedrine. J Pharm Pharmacol 1986; 38: 298-300
- 11 Heymann TD, Bhupulan A, Zureikat NE, Bomanji J, Drinkwater C, Giles P. et al. Khat chewing delays gastric emptying of a semi-solid meal. Aliment Pharmacol Ther 1995; 9: 81-3
- 12 Widler P, Mathys K, Brenneisen R, Kalix P, Fisch HU. Pharmacodynamics and pharmacokinetics of khat: A controlled study. Clin Pharmacol Ther 1994; 55: 556-62
- 13 Nencini P, Ahmed AM, Amiconi G, Elmi AS. Tolerance develops to sympathetic effects of khat in humans. Pharmacology 1984; 28: 150-4