A systematic review of contemporary evidence on SARS-CoV-2 and HIV coinfection: What does it look like up to date?

Mohammad Abrar Shareef; Hafss M Bashaiwth; Abdullah O AlAkbari; Marwan S Bahamran; Maryam O AlAmodi; Salem H Albaiti; Meryam A Ali; Abdulaziz M Eshaq; Khaled Alkattan; Abdulhadi A Alamodi

doi:10.4103/ajm.ajm_175_20

Avicenna Journal of Medicine, Table of Contents

CC BY-NC-ND 4.0 · Avicenna J Med 2020; 10(04): 189-197
DOI: 10.4103/ajm.ajm_175_20

Original Article

A systematic review of contemporary evidence on SARS-CoV-2 and HIV coinfection: What does it look like up to date?

Mohammad Abrar Shareef

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Hafss M Bashaiwth

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Abdullah O AlAkbari

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Marwan S Bahamran

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Maryam O AlAmodi

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Salem H Albaiti

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Meryam A Ali

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Abdulaziz M Eshaq

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Khaled Alkattan

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

,

Abdulhadi A Alamodi

Department of Family Medicine, Sebasticook Valley Hospital, Pittsfield, Maine, USA

› Author Affiliations
Subject Editor:

Abstract

Background: Preexisting alteration of the immune system by factors including older age, cardiovascular diseases, morbid obesity, diabetes, and chronic obstructive pulmonary disease (COPD) have detrimental effects on SARS-CoV-2 patients. Literature regarding SARS-CoV-2/human immunodeficiency virus (HIV) is still developing. Materials and Methods: We reviewed the existing literature pertaining to SARS-CoV-2/HIV coinfection systematically. Research records’ characteristics and patients’ clinical data were collected. Results: Seven research records were included, of which three were case series and four were case reports, reporting a total of 16 cases. There was one case of death, whereas (15/16) patients were discharged home. Majority of patients developed consistent clinical presentation of SARS-CoV-2. All patients had initial positive RT-PCR results, and four cases had HIV-related lymphopenia. Conclusion: Although the current literature is still growing to increase our understanding of SARS-CoV-2/HIV coinfection, people living with HIV should adhere to the guidelines of healthy behavior and practice during this pandemic.

Keywords

Coinfection - COVID-19 - HIV - review - SARS-CoV-2

Full Text

References

References
1 Enjuanes L, Almazán F, Sola I, Zuñiga S. Biochemical aspects of coronavirus replication and virus-host interaction. Annu Rev Microbiol 2006; 60: 211-30
2 Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 2005; 69: 635-64
3 Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S. et al SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-66
4 Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367: 1814-20
5 Nicola M, Alsafi Z, Sohrabi C, Kerwan A, Al-Jabir A, Iosifidis C. et al. The socio-economic implications of the coronavirus and covid-19 pandemic: A review. Int J Surg 2020; 78: 185-93
6 Raoofi A, Takian A, Akbari Sari A, Olyaeemanesh A, Haghighi H, Aarabi M. COVID-19 pandemic and comparative health policy learning in iran. Arch Iran Med 2020; 23: 220-34
7 Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-cov-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents 2020; 55: 105924
8 Available from: https://www.worldometers.info/coronavirus/. [Last accessed on 2020 Apr 28]
9 Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol 2020; 38: 1-9
10 Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: Evidence from meta-analysis. Aging (Albany NY) 2020; 12: 6049-57
11 Marsh K, Eaton JW, Mahy M, Sabin K, Autenrieth CS, Wanyeki I. et al. Global, regional and country-level 90-90-90 estimates for 2018: Assessing progress towards the 2020 target. AIDS 2019; 33: S213-26
12 Wang X, Xu W, Hu G. et al. SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion. Cell Mol Immunol 2020; 1-3
13 Murad MH, Sultan S, Haffar S, Bazerbachi F. Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med 2018; 23: 60-3
14 Altuntas Aydin O, Kumbasar Karaosmanoglu H, Kart Yasar K. HIV/SARS-CoV-2 co-infected patients in Istanbul, Turkey. J Med Virol 2020. [Ahead of print]
15 Wanga M, Luob L, Buc H, Xiad H. Case report: One case of coronavirus disease 2019(COVID-19) in patient co-infected by HIV with a low CD4+ T cell count. IJID 2020; 96: 148-50
16 Riva A, Conti F, Bernacchia D, Pezzati L, Sollima S, Merli S. et al. Darunavir does not prevent SARS-cov-2 infection in HIV patients. Pharmacol Res 2020; 157: 104826
17 Blanco JL, Ambrosioni J, Garcia F, Martínez E, Soriano A, Mallolas J. et al COVID-19 in HIV Investigators. COVID-19 in patients with HIV: Clinical case series. Lancet HIV 2020; 7: e314-6
18 Chen J, Cheng X, Wang R, Zeng X. Computed tomography imaging of an HIV-infected patient with coronavirus disease 2019 (COVID-19). J Med Virol 2020. [Ahead of print]
19 Zhao J, Liao X, Wang H, Wei L, Xing M, Liu L, Zhang Z. Early virus clearance and delayed antibody response in a case of COVID-19 with a history of co-infection with HIV-1 and HCV. Clin Infect Dis 2020. [Ahead of print]
20 Zhu F, Cao Y, Xu S, Zhou M. Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China. J Med Virol 2020; 92: 529-30
21 Kolifarhood G, Aghaali M, Mozafar Saadati H, Taherpour N, Rahimi S, Izadi N. et al. Epidemiological and clinical aspects of COVID-19; a narrative review. Arch Acad Emerg Med 2020; 8: e41
22 Lim J, Jeon S, Shin HY, Kim MJ, Seong YM, Lee WJ. et al. Case of the index patient who caused tertiary transmission of COVID-19 infection in Korea: The application of lopinavir/ritonavir for the treatment of COVID-19 infected pneumonia monitored by quantitative RT-PCR. J Korean Med Sci 2020; 35: e79
23 Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G. et al. A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19. N Engl J Med 2020; 382: 1787-99
24 Center for Disease Control and Prevention (CDC). What to know about COVID-19 and HIV. Accessed on May 2 2020 https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/hiv.html
25 He R, Lu Z, Zhang L, Fan T, Xiong R, Shen X. et al. The clinical course and its correlated immune status in COVID-19 pneumonia. J Clin Virol 2020; 127: 104361
26 Mascolo S, Romanelli A, Carleo MA, Esposito V. Could HIV infection alter the clinical course of SARS-CoV-2 infection? When less is better? J Med Virol 2020. [Ahead of print]
27 Tahamtan A, Ardebili A. Real-time RT-PCR in COVID-19 detection: Issues affecting the results. Expert Rev Mol Diagn 2020; 20: 453-4
28 Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol 2014; 14: 36-49
29 Lee HK, Lee BH, Seok SH, Baek MW, Lee HY, Kim DJ. et al. Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and OC43. J Vet Sci 2010; 11: 165-7
30 Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S. et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol 2020. [Ahead of print]
31 Bao C, Liu X, Zhang H, Li Y, Liu J. Coronavirus disease 2019 (COVID-19) CT findings: A systemic review and meta-analysis. J Am Coll Radiol 2020; 17: 701-9