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DOI: 10.4103/ajns.AJNS_110_21
Multiple cranial nerve involvement as a presentation of primary central nervous system lymphoma: A case-based review

Central nervous system (CNS) lymphoma is of two types: primary and secondary (more common). Primary CNS lymphoma usually presents as parenchymal lesions having characteristic imaging findings and may be associated with leptomeningeal involvement. Involvement of multiple cranial nerves as the initial manifestation of primary CNS lymphoma with the development of typical parenchymal lesions on follow-up is a rare entity. This nerve involvement is termed as neurolymphomatosis. We present the magnetic resonance imaging features of five patients presenting with neurolymphomatosis due to non-Hodgkin's lymphoma.
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Publication History
Received: 15 March 2021
Accepted: 22 May 2021
Article published online:
16 August 2022
© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Mansour A, Qandeel M, Abdel-Razeq H, Abu Ali HA. MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging 2014;14:22.
- 2 Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. Neurolymphomatosis: An international primary CNS lymphoma collaborative group report. Blood 2010;115:5005-11.
- 3 Romano N, Federici M, Castaldi A. Imaging of cranial nerves: A pictorial overview. Insights Imaging 2019;10:33.
- 4 Saremi F, Helmy M, Farzin S, Zee CS, Go JL. MRI of cranial nerve enhancement. AJR Am J Roentgenol 2005;185:1487-97.
- 5 Gan HK, Azad A, Cher L, Mitchell PL. Neurolymphomatosis: Diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol 2010;12:212-5.
- 6 Petluri G, Goyal MK, Singla V, Mittal BR, Nahar U, Modi M, et al. Neurolymphomatosis: A rare cause of multiple mononeuropathy. World J Neurosci 2014;2014:190-3.
- 7 Li JJ, Qiu BS, Chen JX, Liu DW, Xing SH, Chen HB, et al. Multiple cranial nerve deficits as preceding symptoms of systemic non-Hodgkin's lymphoma. CNS Neurosci Ther 2019;25:409.
- 8 Grisold W, Grisold A, Brianai C, Meng S. Lymphoma and the cranial nerves. Clin Oncol 2017;2:1214.
- 9 Haldorsen IS, Espeland A, Larsson EM. Central nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol 2011;32:984-92.
- 10 Weiss GA, Al-Ustwani O, Makdissi R. Multiple cranial nerve palsies as the initial presentation of peripheral T-cell lymphoma. Clin Adv Hematol Oncol 2012;10:620-3.