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CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(03): 706-708
DOI: 10.4103/ajns.AJNS_131_20
Case Report

Tenecteplase-induced nonaneurysmal subarachnoid hemorrhage in a patient with acute ischemic stroke: A case report and literature review

Biplab Das
1   Department of Neurointervention, Institute of Neuroscience, Medanta the Medicity, Haryana
2   Department of Neurology and Interventional Neuroradiology, Fortis Memorial Research Institute, Gurgaon, Haryana
,
Anshu Mahajan
1   Department of Neurointervention, Institute of Neuroscience, Medanta the Medicity, Haryana
,
Gaurav Goel
1   Department of Neurointervention, Institute of Neuroscience, Medanta the Medicity, Haryana
,
Arun Garg
3   Department of Neurology, Institute of Neuroscience, Medanta the Medicity, Gurgaon, Haryana
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Recently, tenecteplase (TNK) has been used for intravenous thrombolysis in acute ischemic stroke (AIS). Although spontaneous subarachnoid hemorrhage (SAH) following thrombolysis with tissue plasminogen activator has been reported, there is a lack of literature regarding TNK-induced nonaneurysmal spontaneous SAH. Our index case received intravenous TNK within an hour of symptom onset of AIS. Following deterioration of sensorium, repeat noncontrast computed tomography was performed, which showed diffuse SAH. Cerebral angiography did not reveal any aneurysm. Nonaneurysmal SAH can be a complication of TNK thrombolysis, which is not reported in literature. Knowledge of this possible adverse reaction is critical for appropriate counseling and management.

Key-words:

Stroke - subarachnoid hemorrhage - tenecteplase - thrombolysis

Financial support and sponsorship

Nil.




Publication History

Received: 01 April 2020

Accepted: 28 May 2020

Article published online:
16 August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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