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CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(04): 1024-1026
DOI: 10.4103/ajns.AJNS_144_20
Case Report

Primary myoepithelial carcinoma of the clivus: A rare presentation

Shilpi Modi
Department of Pathology, Artemis Hospital, Gurgaon, Haryana
,
Deepa Goel
Department of Pathology, Artemis Hospital, Gurgaon, Haryana
,
Pawan Goyal
1   Department of Neurosurgery, Artemis Hospital, Gurgaon, Haryana
,
Aditya Gupta
1   Department of Neurosurgery, Artemis Hospital, Gurgaon, Haryana
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Myoepithelial tumor (MET) of bone is an unusual tumor of uncertain differentiation and histogenesis. Although its presence in various bones has been reported sparsely, the presentation in clivus as primary myoepithelial carcinoma (MEC) has never been reported. They resemble their salivary gland counterparts morphologically and immunohistochemically, but harbor distinct molecular phenotype. At present, moderate nuclear atypia is the acceptable criteria to differentiate MEC from myoepithelioma. Because of their rarity, wide histopathological spectrum, and intraosseous location, MET of bone is easily confused with a variety of primary bone and cartilaginous tumors. Application of immunohistochemistry and, if required, molecular testing are required for making a correct diagnosis. In this article, we describe an extremely rare case of a primary MEC arising from the clivus, which owing to unusual location and immunohistochemical profile was diagnostically challenging.

Key-words:

Clivus - myoepithelial carcinoma - myoepithelial tumor

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Publication History

Received: 07 April 2020

Accepted: 13 August 2020

Article published online:
16 August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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