The usefulness of straight chemotherapy for dermal exposed anaplastic lymphoma kinase fusion-positive anaplastic large-cell lymphoma with intracranial invasion

Hiroyuki Abe; Taishi Nakamura; Masahiro Yoshitomi; Makiko Enaka; Kensuke Tateishi; Norio Shiba; Shoji Yamanaka; Tetsuya Yamamoto

doi:10.4103/ajns.AJNS_158_19

Asian Journal of Neurosurgery, Table of Contents

CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(04): 1218-1221
DOI: 10.4103/ajns.AJNS_158_19

Case Report

The usefulness of straight chemotherapy for dermal exposed anaplastic lymphoma kinase fusion-positive anaplastic large-cell lymphoma with intracranial invasion

Hiroyuki Abe

⁰Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama

,

Taishi Nakamura

⁰Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama

,

Masahiro Yoshitomi

¹Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama

,

Makiko Enaka

²Department of Pathology, Yokohama City University Hospital, Yokohama

,

Kensuke Tateishi

⁰Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama

,

Norio Shiba

¹Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama

,

Shoji Yamanaka

²Department of Pathology, Yokohama City University Hospital, Yokohama

,

Tetsuya Yamamoto

⁰Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama

› Author Affiliations

Abstract

Anaplastic large-cell lymphoma (ALCL) is characterized as extranodal lymphoma and usually chemosensitive disease with overall survival rate of 70%–90%. Prognosis is roughly distinguished by the existence of anaplastic lymphoma kinase (ALK) fusion in tumor cells with higher frequencies observed in the pediatric population, and the outcome of ALK fusion-positive ALCL is relatively good when appropriate treatment is completed. Here, we report a case of dermal-exposed ALK fusion-positive ALCL with intracranial invasion. The patient received straight chemotherapy (ALCL99 protocol) without any plastic or resection surgery. The dermal dehiscence was rapidly healed with controllable local infection, and the tumor was regressed without relapse. Therefore, straight chemotherapy has clinical relevance and is a useful treatment strategy for ALK fusion-positive ALCL with dermal dehiscence.

Key-words:

Anaplastic large cell lymphoma - anaplastic lymphoma kinase fusion intracranial - skin exposure

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References

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