Solitary primary central nervous system plasmablastic lymphoma in a young immunocompetent female: Report on an extremely rare entity with review of literature

Iqbal Mohd; Sanjog Gajbhiye; Ritu Verma; Jayesh Sardhara

doi:10.4103/ajns.AJNS_194_18

Asian Journal of Neurosurgery, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(02): 541-546
DOI: 10.4103/ajns.AJNS_194_18

Case Report

Solitary primary central nervous system plasmablastic lymphoma in a young immunocompetent female: Report on an extremely rare entity with review of literature

Autor*innen

Iqbal Mohd

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
Sanjog Gajbhiye

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
Ritu Verma

¹Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
Jayesh Sardhara

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh

Abstract

Primary central nervous system (CNS) plasmablastic lymphoma (PBL) in immunocompetent patients is an extremely rare disease, and only three cases had been reported till date. We present a case of a young female of age 21 years immunocompetent human immunodeficiency virus (HIV) and Epstein–Barr virus (EBV) negative, presented to us with left frontal lesion with weakness of the right upper and lower limbs for 9 months. Magnetic resonance images showed ring-enhancing lesions resembling a cavernoma or tuberculoma. Histopathological diagnosis was PBL. Surgical excision of tumor, followed by rapid recurrence with bleed in 3-month duration, was treated by adjuvant chemoradiotherapy. We report a young immunocompetent, HIV-negative, and EBV-negative female, with rapidly progressive primary CNS solitary PBL in the posterior frontal region, developed rapid recurrence of the tumor twice despite gross total excision.

Key-words:

Chemoradiotherapy - immunohistochemistry - plasmablastic lymphoma - recurrence

Volltext

Referenzen

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