Context: Supratentorial ependymomas and their anaplastic variants are relatively uncommon
central nervous system neoplasms that afflict both adults and children. Aims: Discuss the clinical and pathological features of patients with anaplastic ependymomas
involving an extraventricular supratentorial location and review modalities and options
of treatment for those rare tumors. Settings and Design: Whereas the treatment algorithm in the pediatric population is well established,
however, treatment in the adult population is less defined. Treatment options are
exposed through the author's cases and review of the literature. Subjects and Methods: In our case series of two adult patients with supratentorial ependymomas World Health
Organization (WHO) Grade III (anaplastic variant), patients presented in both cases
in the emergency room after having a generalized tonic–clonic seizure at home the
first case, and mild hemiparesis the second case. Results: Patients underwent surgical treatment, and a gross total resection was achieved in
both cases. The histopathological examination revealed a diagnosis of anaplastic ependymoma
(WHO Grade III). Both patients had additional radiotherapy, and in the first case,
adjuvant platinum-based chemotherapy was administered due to leptomeningeal gliomatosis.
Conclusion: In our experience, gross total resection was achieved in all patients with supratentorial
extraventricular ependymomas WHO Grade III with additional radiotherapy and platinum-based
chemotherapy. Patients require initial close serial imaging follow-up. The role of
chemotherapy is still uncertain but may be necessary in younger patients and in tumors
that behave more like the pediatric ependymomas.
Key-words:
Anaplastic ependymomas - extraventricular - supratentorial - surgery - treatment
